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  5. Shishijimicin B

Shishijimicin B is an active compound of the enediyne class. Shishijimicin B shows extremely potent cytotoxicity with IC50 values of 2.0-3.3 nM. Shishijimicin B has antitumor activity and can be used for the research of cancer. Shishijimicin B is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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Shishijimicin B Chemical Structure

Shishijimicin B Chemical Structure

CAS No. : 503860-51-3

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Shishijimicin B Related Antibodies

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Description

Shishijimicin B is an active compound of the enediyne class. Shishijimicin B shows extremely potent cytotoxicity with IC50 values of 2.0-3.3 nM. Shishijimicin B has antitumor activity and can be used for the research of cancer[1]. Shishijimicin B is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target

IC50: 3.1 nM (3Y1 cells); 3.3 nM (Hela cells); 2.0 nM (P388 cells)[1]
In Vitro

Shishijimicin B (compound 2) has high cytotoxicity for 3Y1, Hela and P388 cells with IC50 values of 3.1 nM, 3.3 nM and 2.0 nM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Shishijimicin B Related Antibodies
Molecular Weight

935.09

Formula

C45H50N4O12S3
CAS No.
SMILES

CSSSC/C=C([C@]1(C2)O)\C([C@H](C#C/C=C\C#C1)O[C@H](O[C@@H]3C)[C@@H]([C@H]([C@@H]3C(C4=C(NC5=CC=C6O)C(C5=C6)=CC=N4)=O)O)O[C@H](OC[C@@H]7NC(C)C)C[C@@H]7OC)=C(C2=O)NC(OC)=O
Structure Classification
Initial Source

Didemnum proliferum
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Shishijimicin B Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Shishijimicin B503860-51-3Othersactive compoundenediyne classcytotoxicityantitumorcancer3Y1 cellsHela cellsP388 cellsInhibitorinhibitorinhibit

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