2. Immunology/Inflammation
  3. Interleukin Related
  4. Sirukumab

Sirukumab  (Synonyms: CNTO-136)

Cat. No.: HY-P99316 Purity: 95.00%
SDS COA Technical Support

Sirukumab (CNTO-136) is a humanized monoclonal anti-IL6 (Interleukin Related) IgG1κ antibody. Sirukumab binds to IL6, preventing IL6-mediated signal transduction and activation of transcriptional activators, thereby blocking the downstream biological effects of IL6. Sirukumab can be used in the study of active lupus nephritis and rheumatoid arthritis.

For research use only. We do not sell to patients.

CAS No. : 1194585-53-9

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Based on 1 publication(s) in Google Scholar

Sirukumab Related Antibodies

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

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Description

Sirukumab (CNTO-136) is a humanized monoclonal anti-IL6 (Interleukin Related) IgG1κ antibody. Sirukumab binds to IL6, preventing IL6-mediated signal transduction and activation of transcriptional activators, thereby blocking the downstream biological effects of IL6. Sirukumab can be used in the study of active lupus nephritis and rheumatoid arthritis[1][2].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species

Human
Clinical Trial
Molecular Weight

144.6 (kDa)

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Sirukumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Purity & Documentation
References
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Sirukumab Related Classifications

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The dilution calculator equation

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sirukumab1194585-53-9CNTO-136CNTO136CNTO 136Interleukin RelatedILactive lupus nephritishumanized IgG1κ monoclonal antibodyInhibitorinhibitorinhibit

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