Sitagliptin-d₄ phosphate

Cat. No.: HY-13749AS Purity: 95.21%: FAQs
Data Sheet SDS COA Handling Instructions

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Sitagliptin-d₄ (phosphate) is the deuterium labeled Sitagliptin phosphate. Sitagliptin phosphate (MK-0431 phosphate) is a potent inhibitor of DPP4 with an IC50 of 19 nM in Caco-2 cell extracts[1][2].

For research use only. We do not sell to patients.

Sitagliptin-d<sub>4</sub> phosphate Chemical Structure

Sitagliptin-d₄ phosphate Chemical Structure

CAS No. : 1432063-88-1

Size	Price	Stock	Quantity
1 mg	USD 950	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

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Other Forms of Sitagliptin-d₄ phosphate:

Sitagliptin phosphate Get quote

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•Related Small Molecules:

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View All Dipeptidyl Peptidase Isoform Specific Products:

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DPP-1 DPP-2 DPP-4 DPP-8 DPP-9

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

DPP-4

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

509.33

Formula

C₁₆H₁₄D₄F₆N₅O₅P

CAS No.

1432063-88-1

Unlabeled CAS

654671-78-0

Appearance

Oil

Color

Colorless to light yellow

SMILES

P(=O)(O)(O)O.C(F)(F)(F)C=1N2C(CN(C(C[C@@H](CC3=C(F)C=C(F)C(F)=C3)N)=O)C(C2([2H])[2H])([2H])[2H])=NN1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (196.34 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9634 mL	9.8168 mL	19.6336 mL
5 mM	0.3927 mL	1.9634 mL	3.9267 mL
10 mM	0.1963 mL	0.9817 mL	1.9634 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 95.21%

Select Batch:

Data Sheet (272 KB) SDS (252 KB)

COA (247 KB) HNMR (590 KB) RP-HPLC (320 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Thomas, L., et al. (R)-8-(3-amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylm ethyl)-3,7-dihydro-purine-2,6-dione (BI 1356), a novel xanthine-based dipeptidyl peptidase 4 inhibitor, has a superior potency and longer duration of acti [Content Brief]

[3]. Kim, S.J., et al., Dipeptidyl peptidase IV inhibition with MK0431 improves islet graft survival in diabetic NOD mice partially via T-cell modulation. Diabetes, 2009. 58(3): p. 641-51. [Content Brief]

[4]. Sangle, G.V., et al., Novel biological action of the dipeptidylpeptidase-IV inhibitor, sitagliptin, as a glucagon-like peptide-1 secretagogue. Endocrinology, 2012. 153(2): p. 564-73. [Content Brief]

[5]. Kim, S.J., et al., Inhibition of dipeptidyl peptidase IV with sitagliptin (MK0431) prolongs islet graft survival in streptozotocin-induced diabetic mice. Diabetes, 2008. 57(5): p. 1331-9. [Content Brief]

[6]. Beconi, M.G., et al. Disposition of the dipeptidyl peptidase 4 inhibitor sitagliptin in rats and dogs. Drug Metab Dispos, 2007. 35(4): p. 525-32. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9634 mL	9.8168 mL	19.6336 mL	49.0841 mL
	5 mM	0.3927 mL	1.9634 mL	3.9267 mL	9.8168 mL
	10 mM	0.1963 mL	0.9817 mL	1.9634 mL	4.9084 mL
	15 mM	0.1309 mL	0.6545 mL	1.3089 mL	3.2723 mL
	20 mM	0.0982 mL	0.4908 mL	0.9817 mL	2.4542 mL
	25 mM	0.0785 mL	0.3927 mL	0.7853 mL	1.9634 mL
	30 mM	0.0654 mL	0.3272 mL	0.6545 mL	1.6361 mL
	40 mM	0.0491 mL	0.2454 mL	0.4908 mL	1.2271 mL
	50 mM	0.0393 mL	0.1963 mL	0.3927 mL	0.9817 mL
	60 mM	0.0327 mL	0.1636 mL	0.3272 mL	0.8181 mL
	80 mM	0.0245 mL	0.1227 mL	0.2454 mL	0.6136 mL
	100 mM	0.0196 mL	0.0982 mL	0.1963 mL	0.4908 mL