2. Anti-infection
  3. HIV
  4. SJ-3366

SJ-3366 (IQP-0410) is a potent inhibitor of HIV nonnucleoside reverse transcriptase. SJ-3366 (IQP-0410) inhibits HIV at sub-nanomolar concentrations primarily through a typical non-nucleoside mechanism.

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SJ-3366 Chemical Structure

SJ-3366 Chemical Structure

CAS No. : 195720-26-4

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SJ-3366 Related Antibodies

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Description

SJ-3366 (IQP-0410) is a potent inhibitor of HIV nonnucleoside reverse transcriptase[1]. SJ-3366 (IQP-0410) inhibits HIV at sub-nanomolar concentrations primarily through a typical non-nucleoside mechanism[2].

IC50 & Target

nonnucleoside reverse transcriptase[1]
Cellular Effect
Cell Line Type Value Description References
CEM-SS EC50
0.002 μM
Compound: 62, SJ-3386
Antiviral activity against HIV1 RF infected in human CEM-SS cells assessed as inhibition of virus-induced cytopathic effect by XTT assay
Antiviral activity against HIV1 RF infected in human CEM-SS cells assessed as inhibition of virus-induced cytopathic effect by XTT assay
[PMID: 17967909]
CEM-SS EC50
16 μM
Compound: 62, SJ-3386
Antiviral activity against HIV2 ROD infected in human CEM-SS cells assessed as inhibition of virus-induced cytopathic effect by XTT assay
Antiviral activity against HIV2 ROD infected in human CEM-SS cells assessed as inhibition of virus-induced cytopathic effect by XTT assay
[PMID: 17967909]
HeLa EC50
0.07 μM
Compound: 62, SJ-3386
Antiviral activity against HIV1 infected in human HeLa cells expressing CD4-LTR assessed as inhibition of viral entry-related beta galactosidase expression treated for 2 hrs followed by drug wash out measured after 48 hrs by MAGI assay
Antiviral activity against HIV1 infected in human HeLa cells expressing CD4-LTR assessed as inhibition of viral entry-related beta galactosidase expression treated for 2 hrs followed by drug wash out measured after 48 hrs by MAGI assay
[PMID: 17967909]
Molecular Weight

352.43

Formula

C21H24N2O3
CAS No.
SMILES

O=C1NC(C(CC)=C(N1CC2CC=CC2)C(C3=CC(C)=CC(C)=C3)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SJ-3366 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SJ-3366195720-26-4IQP-0410SJ3366SJ 3366IQP0410IQP 0410HIVHuman immunodeficiency virusnonnucleoside reverse transcriptaseInhibitorinhibitorinhibit

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SJ-3366
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HY-118423
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