2. PROTAC Protein Tyrosine Kinase/RTK
  3. PROTACs c-Met/HGFR
  4. SJF-8240

SJF-8240 (PROTAC 7) is a proteolysis targeting chimera (PROTAC) degrader. SJF-8240 induces polyubiquitination of c-Met and inhibits the proliferation of GTL16 cells (IC50=66.7 nM).

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SJF-8240 Chemical Structure

SJF-8240 Chemical Structure

CAS No. : 2230821-68-6

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1 mg USD 250 In-stock
5 mg USD 588 In-stock
10 mg USD 960 In-stock
25 mg USD 2019 In-stock
50 mg USD 3230 In-stock
100 mg USD 5169 In-stock
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Based on 1 publication(s) in Google Scholar

SJF-8240 Related Antibodies

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Description

SJF-8240 (PROTAC 7) is a proteolysis targeting chimera (PROTAC) degrader. SJF-8240 induces polyubiquitination of c-Met and inhibits the proliferation of GTL16 cells (IC50=66.7 nM)[1].

Molecular Weight

1106.24

Formula

C58H65F2N7O11S
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

FC1=CC=C(C=C1)NC(C2(C(NC3=CC(F)=C(C=C3)OC4=CC=NC5=C4C=C(C(OCCCOCCCOCCC(N[C@H](C(N6[C@@H](C[C@H](C6)O)C(NCC7=CC=C(C=C7)C8=C(N=CS8)C)=O)=O)C(C)(C)C)=O)=C5)OC)=O)CC2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (90.40 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9040 mL 4.5198 mL 9.0396 mL
5 mM 0.1808 mL 0.9040 mL 1.8079 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9040 mL 4.5198 mL 9.0396 mL 22.5991 mL
5 mM 0.1808 mL 0.9040 mL 1.8079 mL 4.5198 mL
10 mM 0.0904 mL 0.4520 mL 0.9040 mL 2.2599 mL
15 mM 0.0603 mL 0.3013 mL 0.6026 mL 1.5066 mL
20 mM 0.0452 mL 0.2260 mL 0.4520 mL 1.1300 mL
25 mM 0.0362 mL 0.1808 mL 0.3616 mL 0.9040 mL
30 mM 0.0301 mL 0.1507 mL 0.3013 mL 0.7533 mL
40 mM 0.0226 mL 0.1130 mL 0.2260 mL 0.5650 mL
50 mM 0.0181 mL 0.0904 mL 0.1808 mL 0.4520 mL
60 mM 0.0151 mL 0.0753 mL 0.1507 mL 0.3767 mL
80 mM 0.0113 mL 0.0565 mL 0.1130 mL 0.2825 mL
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SJF-8240 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SJF-82402230821-68-6SJF8240SJF 8240PROTACsc-Met/HGFRGTL16PROTAC degraderc-MetproliferationInhibitorinhibitorinhibit

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