2. Others Immunology/Inflammation MAPK/ERK Pathway Metabolic Enzyme/Protease Autophagy Anti-infection
  3. Isotope-Labeled Compounds Aryl Hydrocarbon Receptor p38 MAPK Endogenous Metabolite Autophagy Bacterial Fungal
  4. Skatole-d8

Skatole-d8  (Synonyms: 3-Methylindole-d8; 3-Methyl-1H-indole-d8)

Cat. No.: HY-W007355S1 Purity: 98.50%
COA Handling Instructions

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Skatole-d8 is the deuterium labeled Skatole. Skatole is produced by intestinal bacteria, regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38[1].

For research use only. We do not sell to patients.

Skatole-d<sub>8</sub> Chemical Structure

Skatole-d8 Chemical Structure

CAS No. : 697807-03-7

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1 mg USD 135 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Skatole-d8:

Skatole-d8 Related Antibodies

Top Publications Citing Use of Products

View All p38 MAPK Isoform Specific Products:

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

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Description

Skatole-d8 is the deuterium labeled Skatole. Skatole is produced by intestinal bacteria, regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38[1].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Skatole-d8 Related Antibodies
Molecular Weight

139.22

Formula

C9HD8N
CAS No.
Unlabeled CAS

83-34-1
Appearance

Solid

Color

White to yellow

SMILES

[2H]C(C1=C([2H])NC2=C1C([2H])=C([2H])C([2H])=C2[2H])([2H])[2H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (718.29 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.1829 mL 35.9144 mL 71.8288 mL
5 mM 1.4366 mL 7.1829 mL 14.3658 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.50%

COA (256 KB) HNMR (254 KB) RP-HPLC (1628 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 7.1829 mL 35.9144 mL 71.8288 mL 179.5719 mL
5 mM 1.4366 mL 7.1829 mL 14.3658 mL 35.9144 mL
10 mM 0.7183 mL 3.5914 mL 7.1829 mL 17.9572 mL
15 mM 0.4789 mL 2.3943 mL 4.7886 mL 11.9715 mL
20 mM 0.3591 mL 1.7957 mL 3.5914 mL 8.9786 mL
25 mM 0.2873 mL 1.4366 mL 2.8732 mL 7.1829 mL
30 mM 0.2394 mL 1.1971 mL 2.3943 mL 5.9857 mL
40 mM 0.1796 mL 0.8979 mL 1.7957 mL 4.4893 mL
50 mM 0.1437 mL 0.7183 mL 1.4366 mL 3.5914 mL
60 mM 0.1197 mL 0.5986 mL 1.1971 mL 2.9929 mL
80 mM 0.0898 mL 0.4489 mL 0.8979 mL 2.2446 mL
100 mM 0.0718 mL 0.3591 mL 0.7183 mL 1.7957 mL
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Skatole-d8 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Skatole-d8697807-03-73-Methylindole-d83-Methyl-1H-indole-d8Isotope-Labeled CompoundsAryl Hydrocarbon Receptorp38 MAPKEndogenous MetaboliteAutophagyBacterialFungalAhRInhibitorinhibitorinhibit

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