2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. SLC13A5-IN-1

SLC13A5-IN-1 is a selective sodium-citrate co-transporter (SLC13A5) inhibitor. SLC13A5-IN-1 completely blocks the uptake of 14C-citrate with an IC50 value of 0.022 μM in HepG2 cells. SLC13A5-IN-1 has the potential for the treatment of metabolic and/or cardiovascular diseases. SLC13A5-IN-1 is extracted from patent WO2018104220A1, Compound I-5.

For research use only. We do not sell to patients.

SLC13A5-IN-1 Chemical Structure

SLC13A5-IN-1 Chemical Structure

CAS No. : 2227548-95-8

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Based on 1 publication(s) in Google Scholar

SLC13A5-IN-1 Related Antibodies

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  • Purity & Documentation

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Description

SLC13A5-IN-1 is a selective sodium-citrate co-transporter (SLC13A5) inhibitor. SLC13A5-IN-1 completely blocks the uptake of 14C-citrate with an IC50 value of 0.022 μM in HepG2 cells. SLC13A5-IN-1 has the potential for the treatment of metabolic and/or cardiovascular diseases. SLC13A5-IN-1 is extracted from patent WO2018104220A1, Compound I-5[1].

IC50 & Target

IC50: 0.022 μM (HepG2/14C-Citrate Uptake Assay); 0.056 μM (recombinant hSLC3A5/14C-Citrate Uptake Assay)[1]
In Vitro

SLC13A5-IN-1 exhibits an IC50 of 0.022 μM in HepG2/14C-Citrate Uptake Assay. HepG2 cells endogenously express hSLC13A5 transporter which is responsible for the uptake of citrate into these cells. Uptake of 14C-citrate can be completely blocked by SLC13A5-IN-1 and the signal can be competed with unlabelled citrate. T[1].
SLC13A5-IN-1 exhibits an IC50 of 0.056 μM in recombinant hSLC3A5/14C-Citrate Uptake Assay[1].
SLC13A5-IN-1 exhibits an IC50 of 100 μM in recombinant Human GlyT2/3H-Glycine Uptake Assay. The human embryonic kidney 293 cells are used that stably over-express the human GlyT2 receptor which is responsible for the uptake of glycine into these cells. Uptake of 3H-glycine can be completely blocked by SLC13A5-IN-1[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SLC13A5-IN-1 Related Antibodies
Molecular Weight

461.79

Formula

C19H19Cl3N2O3S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1CCN(S(=O)(C2=CC(Cl)=CC(Cl)=C2)=O)CC1)NCC3=CC=C(Cl)C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (27.07 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1655 mL 10.8274 mL 21.6549 mL
5 mM 0.4331 mL 2.1655 mL 4.3310 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1655 mL 10.8274 mL 21.6549 mL 54.1372 mL
5 mM 0.4331 mL 2.1655 mL 4.3310 mL 10.8274 mL
10 mM 0.2165 mL 1.0827 mL 2.1655 mL 5.4137 mL
15 mM 0.1444 mL 0.7218 mL 1.4437 mL 3.6091 mL
20 mM 0.1083 mL 0.5414 mL 1.0827 mL 2.7069 mL
25 mM 0.0866 mL 0.4331 mL 0.8662 mL 2.1655 mL
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SLC13A5-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SLC13A5-IN-12227548-95-8Sodium ChannelNa channelsNa+ channelsCitrateUptakemetaboliccardiovasculardiseaseSLC13A5hSLC3A5Inhibitorinhibitorinhibit

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