1. Apoptosis
  2. Apoptosis
  3. SLC7A11-IN-1

SLC7A11-IN-1 is a potent solute carrier family 7 member 11 (SLC7A11, xCT) inhibitor. SLC7A11-IN-1 shows antiproliferative activity. SLC7A11-IN-1 inhibits cell invasion and metastasis. SLC7A11-IN-1 induces Apoptosis and cell cycle arrest at S-phase. SLC7A11-IN-1 shows anti-tumor activity.

For research use only. We do not sell to patients.

SLC7A11-IN-1 Chemical Structure

SLC7A11-IN-1 Chemical Structure

CAS No. : 3049302-90-8

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1 mg USD 348 In-stock
5 mg USD 870 In-stock
10 mg USD 1180 In-stock
25 mg USD 1980 In-stock
50 mg USD 2980 In-stock
100 mg USD 4380 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

SLC7A11-IN-1 is a potent solute carrier family 7 member 11 (SLC7A11, xCT) inhibitor. SLC7A11-IN-1 shows antiproliferative activity. SLC7A11-IN-1 inhibits cell invasion and metastasis. SLC7A11-IN-1 induces Apoptosis and cell cycle arrest at S-phase. SLC7A11-IN-1 shows anti-tumor activity[1].

IC50 & Target

SLC7A11[1]

In Vitro

SLC7A11-IN-1 (compound 2; 0-100 µM; 72 h) shows antiproliferative activity with IC50s of 0.03, 0.11, 0.18, 0.17, 0.27 µM for HCT-116, MDA-MB-231, MCF-7, HepG2, LO2 cells, respectively[1].
SLC7A11-IN-1 (0.5 µM; 24 h) inhibits invasion and metastasis of HCT-116 cells[1].
SLC7A11-IN-1 (0.5 µM; 24 h) induces cell apoptosis and cell cycle arrest at S-phase[1].
SLC7A11-IN-1 obviously reduces the intracellular GSH content and significantly enhances reactive oxygen species (ROS) expression[1].
SLC7A11-IN-1 (1 µM; 15 h) significantly induced DNA damage and related proteins expression in HCT-116 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis[1]

Cell Line: HCT-116 cells
Concentration: 0.5 µM
Incubation Time: 24 h
Result: Induced cell apoptosis and cell cycle arrest at S-phase with the S-phase proportion of 55.79%.

Western Blot Analysis[1]

Cell Line: HCT-116 cells
Concentration: 1 µM
Incubation Time: 15 h
Result: Increased the expression of p53, Bax, p-Akt, VEGFA and HIF1-α proteins, decreased the expression of Bcl-2, xCT protein level.
In Vivo

SLC7A11-IN-1 (2 mg/kg; i.v.; every three days for consecutive 3 times) inhibits the growth of tumors in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: male BALB/c mice (CT26 tumor models)[1]
Dosage: 2 mg/kg
Administration: I.v.; once every three days, for consecutive 3 times
Result: Suppressed the growth of tumor by 60.7%.
Molecular Weight

664.35

Formula

C13H17Cl2F3N4O5PtS

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[NH3][Pt+4]([OH-])([Cl-])([Cl-])([O-]C(CCCC(NC1=NC2=CC=C(C=C2S1)OC(F)(F)F)=O)=O)[NH3]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 20 mg/mL (30.10 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5052 mL 7.5262 mL 15.0523 mL
5 mM 0.3010 mL 1.5052 mL 3.0105 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Working solution concentration: mg/mL
Purity & Documentation

Purity: 95.93%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5052 mL 7.5262 mL 15.0523 mL 37.6308 mL
5 mM 0.3010 mL 1.5052 mL 3.0105 mL 7.5262 mL
10 mM 0.1505 mL 0.7526 mL 1.5052 mL 3.7631 mL
15 mM 0.1003 mL 0.5017 mL 1.0035 mL 2.5087 mL
20 mM 0.0753 mL 0.3763 mL 0.7526 mL 1.8815 mL
25 mM 0.0602 mL 0.3010 mL 0.6021 mL 1.5052 mL
30 mM 0.0502 mL 0.2509 mL 0.5017 mL 1.2544 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
SLC7A11-IN-1
Cat. No.:
HY-149979
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