2. GPCR/G Protein Immunology/Inflammation
  3. CXCR
  4. SLW131

SLW131 (Compound 10) is the antagonist for CCR7 with a good affinity of Ki of 9.85 nM. SLW131 inhibits CCL19-induced Go protein activation with an IC50 of 29.4 μM, inhibits β-arrestin2 recruitment with an IC50 of 6.0 μM. SLW131 inhibits CCL19-induced cell morphological changes in primary BMDCs, and CCR7-mediated migration in mouse CD4+ T cell.

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SLW131 Chemical Structure

SLW131 Chemical Structure

CAS No. : 681511-84-2

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SLW131 Related Antibodies

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Description

SLW131 (Compound 10) is the antagonist for CCR7 with a good affinity of Ki of 9.85 nM. SLW131 inhibits CCL19-induced Go protein activation with an IC50 of 29.4 μM, inhibits β-arrestin2 recruitment with an IC50 of 6.0 μM. SLW131 inhibits CCL19-induced cell morphological changes in primary BMDCs, and CCR7-mediated migration in mouse CD4+ T cell[1].

IC50 & Target

Ki: CCR7 (9.85 nM)
Molecular Weight

461.53

Formula

C21H27N5O5S
CAS No.
SMILES

O=C(C1=CC=CC(NC(C(N[C@H](C(C)(C)C)C2=CC=C(O2)C)=N3)=NS3(=O)=O)=C1O)N(C)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SLW131 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SLW131681511-84-2SLW 131SLW-131CXCRCXC chemokine receptorsC-X-C motif chemokine receptorsInhibitorinhibitorinhibit

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