2. Metabolic Enzyme/Protease
  3. E1/E2/E3 Enzyme
  4. Smurf1 modulator-1

Smurf1 modulator-1 (Compound 20) is a selective inhibitor for Smad ubiquitination regulatory factor 1 (Smurf1), with IC50 of 180 nM.

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Smurf1 modulator-1 Chemical Structure

Smurf1 modulator-1 Chemical Structure

CAS No. : 1825371-51-4

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1 mg USD 215 In-stock
5 mg USD 530 In-stock
10 mg USD 760 In-stock
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Smurf1 modulator-1 Related Antibodies

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Description

Smurf1 modulator-1 (Compound 20) is a selective inhibitor for Smad ubiquitination regulatory factor 1 (Smurf1), with IC50 of 180 nM[1].

Molecular Weight

446.54

Formula

C23H34N4O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1N(C2CCCCC2)N(C(C)=C1NC(C3=NOC([C@H]4[C@@H](OC(C)(CO4)C)C)=C3C)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (279.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2394 mL 11.1972 mL 22.3944 mL
5 mM 0.4479 mL 2.2394 mL 4.4789 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2394 mL 11.1972 mL 22.3944 mL 55.9860 mL
5 mM 0.4479 mL 2.2394 mL 4.4789 mL 11.1972 mL
10 mM 0.2239 mL 1.1197 mL 2.2394 mL 5.5986 mL
15 mM 0.1493 mL 0.7465 mL 1.4930 mL 3.7324 mL
20 mM 0.1120 mL 0.5599 mL 1.1197 mL 2.7993 mL
25 mM 0.0896 mL 0.4479 mL 0.8958 mL 2.2394 mL
30 mM 0.0746 mL 0.3732 mL 0.7465 mL 1.8662 mL
40 mM 0.0560 mL 0.2799 mL 0.5599 mL 1.3997 mL
50 mM 0.0448 mL 0.2239 mL 0.4479 mL 1.1197 mL
60 mM 0.0373 mL 0.1866 mL 0.3732 mL 0.9331 mL
80 mM 0.0280 mL 0.1400 mL 0.2799 mL 0.6998 mL
100 mM 0.0224 mL 0.1120 mL 0.2239 mL 0.5599 mL
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Smurf1 modulator-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Smurf1 modulator-11825371-51-4E1/E2/E3 EnzymeE1 activating enzymeE2 conjugating enzymeE3 ligating enzymeUbiquitin activating enzymeUbiquitin conjugating enzymeUbiquitin ligasepulmonary arterial hypertensionglaucomahereditary hemorrhagic telangiectasiaHHTproteinuriawound healingCOPDasthmaInhibitorinhibitorinhibit

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