2. PI3K/Akt/mTOR
  3. PI3K mTOR
  4. SN32976

SN32976 is a potent and selective class I PI3K and mTOR inhibitor with IC50s of 15.1 nM, 461 nM, 110 nM, 134 nM and 194 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ and mTOR, respectively. SN32976 shows high selectivity among other 442 kinases. SN32976 shows anticancer effects.

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SN32976 Chemical Structure

SN32976 Chemical Structure

CAS No. : 1246202-11-8

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Based on 1 publication(s) in Google Scholar

SN32976 Related Antibodies

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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Description

SN32976 is a potent and selective class I PI3K and mTOR inhibitor with IC50s of 15.1 nM, 461 nM, 110 nM, 134 nM and 194 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ and mTOR, respectively. SN32976 shows high selectivity among other 442 kinases. SN32976 shows anticancer effects[1].

IC50 & Target[1]

PI3Kα

15.1 nM (IC50)

PI3Kβ

461 nM (IC50)

PI3Kγ

110 nM (IC50)

PI3Kδ

134 nM (IC50)

mTOR

194 nM (IC50)

Cellular Effect
Cell Line Type Value Description References
Sf9 IC50
206 nM
Compound: SN32976; 16
Inhibition of recombinant human N-terminal p110delta/p85alpha expressed in baculovirus infected Sf9 insect cells using PIP2 as substrate by HTRF assay
Inhibition of recombinant human N-terminal p110delta/p85alpha expressed in baculovirus infected Sf9 insect cells using PIP2 as substrate by HTRF assay
[PMID: 30850264]
Sf9 IC50
5.3 nM
Compound: SN32976; 16
Inhibition of recombinant human N-terminal p110alpha/p85alpha expressed in baculovirus infected Sf9 insect cells using PIP2 as substrate by HTRF assay
Inhibition of recombinant human N-terminal p110alpha/p85alpha expressed in baculovirus infected Sf9 insect cells using PIP2 as substrate by HTRF assay
[PMID: 30850264]
Sf9 IC50
743 nM
Compound: SN32976; 16
Inhibition of recombinant human N-terminal p110beta/p85alpha expressed in baculovirus infected Sf9 insect cells using PIP2 as substrate by HTRF assay
Inhibition of recombinant human N-terminal p110beta/p85alpha expressed in baculovirus infected Sf9 insect cells using PIP2 as substrate by HTRF assay
[PMID: 30850264]
In Vitro

SN32976 (1-100 nM; for 1 h) inhibits both Thr308 and Ser473 pAKT expression in U-87 MG cells at concentrations as low as 10 nM[1].
The cell lines are PTEN null (U-87 MG, PC3, NZM34), H1047R PIK3CA mutant (HCT116, NZM40), E545K PIK3CA mutant (NCI-H460, MCF7) and PIK3CA amplified (FaDu). SN32976 potently inhibits cell proliferation in all cell lines, with EC50 values ranging from 18.5 nM in NCI-H460 cells to 1787 nM in NZM34 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SN32976 Related Antibodies

Western Blot Analysis[1]

Cell Line: U-87 MG cells
Concentration: 1 nM, 3 nM, 10 nM, 30 nM, 100 nM
Incubation Time: for 1 h
Result: Inhibited both Thr308 and Ser473 pAKT expression in U-87 MG cells.
In Vivo

SN32976 (37.5-75 mg/kg; po; daily; for 21 days) inhibits tumor growth in U-87 MG tumor xenograft models[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-8 week old female balb/c nude or female balb/c Rag1−/− mice inoculated with U-87 MG cells[1]
Dosage: 37.5 mg/kg; 75 mg/kg
Administration: po; daily; for 21 days
Result: Inhibited tumor growth in U-87 MG tumor xenograft models.
Molecular Weight

581.64

Formula

C24H33F2N9O4S
CAS No.
SMILES

O=S(CCN(C)C)(N1CCN(C2=NC(N3C4=CC=CC(OC)=C4N=C3C(F)F)=NC(N5CCOCC5)=N2)CC1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SN32976 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SN329761246202-11-8SN 32976SN-32976PI3KmTORPhosphoinositide 3-kinaseMammalian target of Rapamycinclass I PI3KPI3KαPI3KβPI3KγPI3Kδanticancer effectsInhibitorinhibitorinhibit

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