2. Others NF-κB Apoptosis
  3. Biochemical Assay Reagents NF-κB Apoptosis
  4. Sodium benzoate

Sodium benzoate is an orally active pharmaceutical excipient, such as an antibacterial agent, preservative, lubricant, etc. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs.Sodium benzoate activates NF-κB and induces Apoptosis. Sodium benzoate induces immune suppression and produces reproductively toxic. Sodium benzoate can be used for colon cancer and immune disease research.

For research use only. We do not sell to patients.

Sodium benzoate Chemical Structure

Sodium benzoate Chemical Structure

CAS No. : 532-32-1

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Based on 1 publication(s) in Google Scholar

Other Forms of Sodium benzoate:

Sodium benzoate Related Antibodies

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Description

Sodium benzoate is an orally active pharmaceutical excipient, such as an antibacterial agent, preservative, lubricant, etc. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs.Sodium benzoate activates NF-κB and induces Apoptosis. Sodium benzoate induces immune suppression and produces reproductively toxic. Sodium benzoate can be used for colon cancer and immune disease research[1][2][3][4][5].

In Vitro

Sodium benzoate (0.125-3 mg/mL, 48 h) does not completely protect the PC12 cells to aluminum-induced free radicals toxicity[4].
Sodium benzoate (0-2500 mg/mL, 72 h) affects the functional and activation status of splenocytes at non cytotoxic dose, with inducing immune suppression[5].
Sodium benzoate (0.39-200 mM, 24 h) activates NF-κB and induces apoptosis in HCT116 cells[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sodium benzoate Related Antibodies
In Vivo

Sodium benzoate (125-500 ppm, diet, 8 weeks) affects body weight, food intake, lipid profile and biochemical indices of kidney and liver function in mice[2].
Sodium benzoate (0-1000 mg/kg, p.o., 90 consecutive days) is dose-dependently reproductively toxic to male rats, with reducing sperm parameters, alters plasma levels of sex hormones[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

144.10

Formula

C7H5NaO2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O[Na])C1=CC=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Store at room temperature 3 years

In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (693.96 mM)

DMSO : 5 mg/mL (34.70 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.9396 mL 34.6981 mL 69.3962 mL
5 mM 1.3879 mL 6.9396 mL 13.8792 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

SDS (393 KB)

COA (249 KB) HNMR (127 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 6.9396 mL 34.6981 mL 69.3962 mL 173.4906 mL
5 mM 1.3879 mL 6.9396 mL 13.8792 mL 34.6981 mL
10 mM 0.6940 mL 3.4698 mL 6.9396 mL 17.3491 mL
15 mM 0.4626 mL 2.3132 mL 4.6264 mL 11.5660 mL
20 mM 0.3470 mL 1.7349 mL 3.4698 mL 8.6745 mL
25 mM 0.2776 mL 1.3879 mL 2.7758 mL 6.9396 mL
30 mM 0.2313 mL 1.1566 mL 2.3132 mL 5.7830 mL
H2O 40 mM 0.1735 mL 0.8675 mL 1.7349 mL 4.3373 mL
50 mM 0.1388 mL 0.6940 mL 1.3879 mL 3.4698 mL
60 mM 0.1157 mL 0.5783 mL 1.1566 mL 2.8915 mL
80 mM 0.0867 mL 0.4337 mL 0.8675 mL 2.1686 mL
100 mM 0.0694 mL 0.3470 mL 0.6940 mL 1.7349 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Sodium benzoate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sodium532-32-1Biochemical Assay ReagentsNF-κBApoptosisNuclear factor-κBNuclear factor-kappaBpharmaceutical excipientpharmaceutical auxiliariepharmaceutical ingredientsinactive ingredientsstabilitysolubilityprocessabilityabsorptiondistributionmetabolismand elimination (ADME)Inhibitorinhibitorinhibit

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