2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. SOR-C13 TFA

SOR-C13 TFA, a carboxy-terminal truncated peptide, is a high-affinity TRPV6 antagonist with an IC50 value of 14 nM. TRPV6 is a non-voltage gated calcium channel that is associated with malignancy and poor prognosis in breast cancer. SOR-C13 TFA has anticancer activity.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

SOR-C13 TFA Chemical Structure

SOR-C13 TFA Chemical Structure

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5 mg USD 180 In-stock
10 mg USD 280 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of SOR-C13 TFA:

SOR-C13 TFA Related Antibodies

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Description

SOR-C13 TFA, a carboxy-terminal truncated peptide, is a high-affinity TRPV6 antagonist with an IC50 value of 14 nM. TRPV6 is a non-voltage gated calcium channel that is associated with malignancy and poor prognosis in breast cancer. SOR-C13 TFA has anticancer activity[1].

IC50 & Target[1]

TRPV6

14 nM (IC50)

In Vivo

SOR-C13 (i.p.; 400,600, 800 mg/kg; daily; on days 1 to 12) TFA can effectively inhibit the growth of tumor in female NOD/SCID mice with SKOV-3 cell[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female NOD/SCID mice with SKOV-3 cell[2]
Dosage: 400, 600, 800 mg/kg
Administration: IP; daily; on days 1 to 12
Result: Effectively inhibited the growth of tumor.
Molecular Weight

1565.81 (free acid)

Formula

C72H116N20O19.xC2HF3O2
Appearance

Solid

Color

White to off-white

Sequence

Lys-Glu-Phe-Leu-His-Pro-Ser-Lys-Val-Asp-Leu-Pro-Arg
Sequence Shortening

KEFLHPSKVDLPR
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (Need ultrasonic)

DMSO : 100 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References
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SOR-C13 TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SOR-C13TRP ChannelTransient receptor potential channelsTRPV6calcium channelanticancerbreast cancerInhibitorinhibitorinhibit

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