2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. SOR-C13

SOR-C13, a carboxy-terminal truncated peptide, is a high-affinity TRPV6 antagonist with an IC50 value of 14 nM. TRPV6 is a non-voltage gated calcium channel that is associated with malignancy and poor prognosis in breast cancer. SOR-C13 has anticancer activity.

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SOR-C13 Chemical Structure

SOR-C13 Chemical Structure

CAS No. : 1187852-48-7

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Based on 1 publication(s) in Google Scholar

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Description

SOR-C13, a carboxy-terminal truncated peptide, is a high-affinity TRPV6 antagonist with an IC50 value of 14 nM. TRPV6 is a non-voltage gated calcium channel that is associated with malignancy and poor prognosis in breast cancer. SOR-C13 has anticancer activity[1].

IC50 & Target[1]

TRPV6

14 nM (IC50)

In Vivo

SOR-C13 (i.p.; 400,600, 800 mg/kg; daily; on days 1 to 12) can effectively inhibit the growth of tumor in female NOD/SCID mice with SKOV-3 cell[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female NOD/SCID mice with SKOV-3 cell[2]
Dosage: 400,600, 800 mg/kg
Administration: IP; daily; on days 1 to 12
Result: Effectively inhibited the growth of tumor.
Molecular Weight

1565.81

Formula

C72H116N20O19
CAS No.
Appearance

Solid

Color

White to off-white

Sequence Shortening

KEFLHPSKVDLPR
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Purity: 98.56%

SDS (252 KB)

COA (245 KB) RP-HPLC (110 KB) MS (205 KB)

Handling Instructions (2659 KB)
References
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SOR-C13 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SOR-C131187852-48-7TRP ChannelTransient receptor potential channelsTRPV6calcium channelanticancerbreast cancerInhibitorinhibitorinhibit

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