SP3N hydrochloride

Cat. No.: HY-161794A: FAQs
Data Sheet Handling Instructions Technical Support

SP3N hydrochloride is a specific degrader of the prolyl isomerase (FKBP12). The alkylamine of SP3N hydrochloride is metabolized to a reactive aldehyde (SP3CHO), which recruits the SCF^FBXO22 ligase for FKBP12 degradation. SP3N hydrochloride may be used in research for cancer.

For research use only. We do not sell to patients.

SP3N hydrochloride Chemical Structure

Size		Stock
MOQ		Minimum order quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote
Other size		Get quote

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This product is a controlled substance and not for sale in your territory.

Other Forms of SP3N hydrochloride:

SP3N Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

764.34

Formula

C₃₉H₅₈ClN₃O₁₀

SMILES

COC1=CC=C(CC[C@@H](OC([C@@H]2CCCCN2C(C(C(C)(C)CC)=O)=O)=O)C3=CC(NC(CCOCCOCCOCCN)=O)=CC=C3)C=C1OC.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (130.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.3083 mL	6.5416 mL	13.0832 mL
5 mM	0.2617 mL	1.3083 mL	2.6166 mL
10 mM	0.1308 mL	0.6542 mL	1.3083 mL

View the Complete Stock Solution Preparation Table

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

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In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Kagiou C, et al. Alkylamine-tethered molecules recruit FBXO22 for targeted protein degradation[J]. Nature Communications, 2024, 15(1): 5409. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.3083 mL	6.5416 mL	13.0832 mL	32.7080 mL
	5 mM	0.2617 mL	1.3083 mL	2.6166 mL	6.5416 mL
	10 mM	0.1308 mL	0.6542 mL	1.3083 mL	3.2708 mL
	15 mM	0.0872 mL	0.4361 mL	0.8722 mL	2.1805 mL
	20 mM	0.0654 mL	0.3271 mL	0.6542 mL	1.6354 mL
	25 mM	0.0523 mL	0.2617 mL	0.5233 mL	1.3083 mL
	30 mM	0.0436 mL	0.2181 mL	0.4361 mL	1.0903 mL
	40 mM	0.0327 mL	0.1635 mL	0.3271 mL	0.8177 mL
	50 mM	0.0262 mL	0.1308 mL	0.2617 mL	0.6542 mL
	60 mM	0.0218 mL	0.1090 mL	0.2181 mL	0.5451 mL
	80 mM	0.0164 mL	0.0818 mL	0.1635 mL	0.4088 mL
	100 mM	0.0131 mL	0.0654 mL	0.1308 mL	0.3271 mL