2. Metabolic Enzyme/Protease
  3. Phospholipase
  4. Sphingolactone-24

Sphingolactone-24 (Sph-24) is a selective and irreversible neutral sphingomyelinase (nSMase) inhibitor. Sphingolactone-24 has the potential for the research of acute lung injury.

For research use only. We do not sell to patients.

Sphingolactone-24 Chemical Structure

Sphingolactone-24 Chemical Structure

CAS No. : 881177-99-7

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Sphingolactone-24 Related Antibodies

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Description

Sphingolactone-24 (Sph-24) is a selective and irreversible neutral sphingomyelinase (nSMase) inhibitor. Sphingolactone-24 has the potential for the research of acute lung injury[1].

In Vitro

Sphingolactone-24 (50 µM; 30 min+24 h) inhibits LPS-induced p38 MAPK phosphorylation and antagonized the antiapoptotic effect LPS (HY-D1056)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sphingolactone-24 Related Antibodies

Western Blot Analysis[1]

Cell Line: human neutrophils
Concentration: 50 µM
Incubation Time: 30 min +24 h (30 min before LPS (500 ng/ml) treatment)
Result: Inhibited LPS-induced p38 MAPK phosphorylation and antagonized the antiapoptotic effect of LPS.
In Vivo

Sphingolactone-24 (1 mg/kg; i.p.; 3 and 9 h thereafter LPS) reduces the severity of LPS-induced ALI and increases the survival rate of LPS-induced lung injury mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C3H/HeN breeder mice (LPS 10 mg/kg; intranasal instillation)[1]
Dosage: 1 mg/kg
Administration: I.p.; 3 and 9 h thereafter LPS
Result: Improved survival and reduced the severity of LPS-induced acute lung injury (ALI).
Molecular Weight

323.43

Formula

C18H29NO4
CAS No.
SMILES

C/C=C/C=C/C(N[C@H]([C@@]1([H])CC(C(O1)=O)CCCCCC)CO)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Sphingolactone-24 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sphingolactone-24881177-99-7Sph-24Sphingolactone24Sphingolactone 24Sph24Sph 24Phospholipasehuman neutrophilsLPSacute lung injuryp38 MAPKantiapoptoticInhibitorinhibitorinhibit

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