2. Metabolic Enzyme/Protease
  3. GSNOR
  4. SPL-334

SPL-334 is a potent and selective S-Nitrosoglutathione reductase (GSNOR) inhibitor. SPL-334 causes a significant reduction in the production of Th2 cytokines IL-5 and IL-13 and the levels of the chemokine CCL11 (eotaxin-1) in the airways. SPL-334 can be used in research of allergic airway inflammation.

For research use only. We do not sell to patients.

SPL-334 Chemical Structure

SPL-334 Chemical Structure

CAS No. : 688347-51-5

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Based on 1 publication(s) in Google Scholar

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Description

SPL-334 is a potent and selective S-Nitrosoglutathione reductase (GSNOR) inhibitor. SPL-334 causes a significant reduction in the production of Th2 cytokines IL-5 and IL-13 and the levels of the chemokine CCL11 (eotaxin-1) in the airways. SPL-334 can be used in research of allergic airway inflammation[1].

In Vivo

SPL-334 (0.1-1 mg/kg; Intranasal administration; daily, for 7 d; BALB/c recipient mice with DO11.10 CD4+ Th2 xenograft) causes a reduction in allergic airway inflammation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c recipient mice with DO11.10 CD4+ Th2 xenograft[1]
Dosage: 0.1 or 1 mg/kg
Administration: Intranasal administration; daily, for 7 days
Result: Caused a significant reduction in the influx of lymphocytes and eosinophils into the airways and the level of EPO in the BALF.
Reduced the number of OVA-specific T cells and eosinophils during allergic airway inflammation.
Reduced in peribronchial inflammation and mucus secretion during airway inflammation.
Molecular Weight

433.50

Formula

C22H15N3O3S2
CAS No.
SMILES

N#CC1=C(CSC2=NC3=C(C(N2CC4=CC=C(C(O)=O)C=C4)=O)SC=C3)C=CC=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SPL-334 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SPL-334688347-51-5SPL334SPL 334GSNORS-nitrosoglutathione reductaseTh2 cytokinesIL-5IL-13chemokine CCL11allergic airway inflammationInhibitorinhibitorinhibit

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