2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. GSNOR

GSNOR

S-nitrosoglutathione reductase

GSNOR

Related Products

PDF 0.07 MB

S-Nitrosoglutathione reductase (GSNOR) is a member of the alcohol dehydrogenase family (ADH) that regulates the levels of S-nitrosothiols (SNOs) through catabolism of S-nitrosoglutathione (GSNO).

GSNOR reduces the nitric oxide (NO) adduct S-nitrosoglutathione (GSNO), an essential reservoir for NO bioactivity. In plants, GSNOR has been found to be important in resistance to bacterial and fungal pathogens. GSNOR is ubiquitously expressed and catalyzes denitrosylation of GSNO, thereby downregulating protein S-nitrosylation in β-cells.

GSNOR activity appears to be necessary for normal development and fertility under optimal growth conditions.

GSNOR Related Products (3):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-14984
    N6022
    		Inhibitor 99.91%
    N6022 is a potent, selective, reversible, and efficacious S-Nitrosoglutathione reductase(GSNOR) inhibitor with IC50 of 8 nM.
    N6022
  • HY-109027
    Cavosonstat
    		Inhibitor 99.36%
    Cavosonstat (N91115) is an orally active S-nitrosoglutathione reductase (GSNOR) inhibitor. Cavosonstat is a CFTR stabilizer, and can be used for cystic fibrosis research.
    Cavosonstat
  • HY-110295
    SPL-334
    		Inhibitor
    SPL-334 is a potent and selective S-Nitrosoglutathione reductase (GSNOR) inhibitor. SPL-334 causes a significant reduction in the production of Th2 cytokines IL-5 and IL-13 and the levels of the chemokine CCL11 (eotaxin-1) in the airways. SPL-334 can be used in research of allergic airway inflammation.
    SPL-334