2. Anti-infection Metabolic Enzyme/Protease
  3. SARS-CoV Cathepsin
  4. SPR38

SPR38 is a potent SARS-CoV-2 main protease inhibitor, with a Ki of 0.260 μM. SPR38 also inhibits hCatL and hCatB, with Ki values of 1.92 μM and 11.1 μM, respectively.

For research use only. We do not sell to patients.

SPR38 Chemical Structure

SPR38 Chemical Structure

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SPR38 Related Antibodies

Top Publications Citing Use of Products

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Cathepsin B Cathepsin C Cathepsin D Cathepsin E Cathepsin K Cathepsin L Cathepsin S

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Description

SPR38 is a potent SARS-CoV-2 main protease inhibitor, with a Ki of 0.260 μM. SPR38 also inhibits hCatL and hCatB, with Ki values of 1.92 μM and 11.1 μM, respectively[1].

IC50 & Target

cathepsin L

1.92 ± 0.1 μM (IC50)

Cathepsin B

11.1 ± 1.2 μM (IC50)

In Vitro

SPR38 shows no inhibition at 100 μM against SARS-CoV-2 papain-like protease (PLpro), which plays a crucial role in processing viral polyproteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SPR38 Related Antibodies
Molecular Weight

443.54

Formula

C24H33N3O5
SMILES

O=C(OCC1=CC=CC=C1)N[C@@H](CCCC)C(N[C@H](/C=C/C(C)=O)C[C@H]2C(NCC2)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SPR38 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SPR38SPR 38SPR-38SARS-CoVCathepsinSARS coronavirusSARS-CoV-2hCatLhCatBviralpolyproteinsmain proteaseInhibitorinhibitorinhibit

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