2. PI3K/Akt/mTOR
  3. PI3K
  4. SR-3-65

SR-3-65 (compound 6) is a Indisulam (HY-13650) derivative,and inhibits the migration of gastric cancer cells. SR-3-65 attenuates PI3K/AKT/GSK-3β/β-catenin signaling pathway.

For research use only. We do not sell to patients.

SR-3-65 Chemical Structure

SR-3-65 Chemical Structure

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SR-3-65 Related Antibodies

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Description

SR-3-65 (compound 6) is a Indisulam (HY-13650) derivative,and inhibits the migration of gastric cancer cells. SR-3-65 attenuates PI3K/AKT/GSK-3β/β-catenin signaling pathway[1].

In Vitro

SR-3-65 (0.0001-100 µM, 48h) inhibits the cell growth of AGS cells with the IC50 of 24.75 μM[1].
SR-3-65 (10 µM, 48-72 h) shows anti-migration activity in AGS and MGC803 cells[1].
SR-3-65 (10 µM, 48 h) upregulates E-cadherin and downregulated N-cadherin and vimentin in AGS and MGC803 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SR-3-65 Related Antibodies

Cell Viability Assay[1]

Cell Line: AGS cells
Concentration: 0.0001-100 µM
Incubation Time: 48 h
Result: Inhibited the cell growth of AGS cells with the IC50 of 24.75 μM。

Cell Migration Assay [1]

Cell Line: AGS and MGC803 cells
Concentration: 10 µM
Incubation Time: 48-72 h
Result: Showed anti-migration activity in AGS and MGC803 cells.

Western Blot Analysis[1]

Cell Line: MGC803 cells
Concentration: 10 µM
Incubation Time: 48 h
Result: Upregulated E-cadherin and downregulated N-cadherin and vimentin.
Molecular Weight

399.77

Formula

C16H9ClF3N3O2S
SMILES

O=S(C1=CC=CC(C#N)=C1)(NC2=CC(C(F)(F)F)=CC3=C2NC=C3Cl)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SR-3-65 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SR-3-65PI3KPhosphoinositide 3-kinaseAGSindisulam derivativesInhibitory effectMigrationMGC803Inhibitorinhibitorinhibit

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SR-3-65
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HY-161362
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