SS47

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SS47, a PROTAC-based HPK1 degrader, exerts proteasome-mediated HPK1 degradation. The degradation of HPK1 via SS47 also significantly enhances the antitumor efficacy.

For research use only. We do not sell to patients.

SS47 Chemical Structure

CAS No. : 2636072-62-1

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Biological Activity
Purity & Documentation
References
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Description

SS47, a PROTAC-based HPK1 degrader, exerts proteasome-mediated HPK1 degradation. The degradation of HPK1 via SS47 also significantly enhances the antitumor efficacy^[1].

IC₅₀ & Target

HPK1

In Vitro

SS47 (100 nM, 24 h) has antitumor effect in CAR-T cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SS47 (10 mg/kg, Subcutaneous injection, once a day for 10 days from day 5) can degrade HPK1 in 4T-1 tumor-bearing mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	4T-1 tumor-bearing mice^[1]
Dosage:	10 mg/kg
Administration:	Subcutaneous injection (s.c.)
Result:	Exerted protea-some-mediated HPK1 degradation within 48 h.

Molecular Weight

953.07

Formula

C₄₉H₅₆N₆O₁₂S

CAS No.

2636072-62-1

SMILES

O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3OCCOCCOCCOCCOCCC(N4CCC(C5=NC=C(C6=CC(OCC7=CC=CC(C#CC(C)(O)C)=C7)=C(N)N=C6)S5)CC4)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Si J, et al. Hematopoietic progenitor kinase1 (HPK1) mediates T cell dysfunction and is a druggable target for T cell-based immunotherapies [J]. Cancer Cell, 2020, 38(4): 551-566. e11. [Content Brief]

SS47 Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SS472636072-62-1SS 47SS-47PROTACsMAP4KMAPK Kinase Kinase KinasePROTACHPK1 CAR-T4T-1 tumor-bearing miceInhibitorinhibitorinhibit

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