2. Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. Nuclear Hormone Receptor 4A/NR4A Mitochondrial Metabolism
  4. ST-CY14

ST-CY14 is an inhibitor for Nur77-PPARγ interaction with an EC50 of 3.15 μM, that binds to Nur77 (Kd=32 nM), blocks Nur77 from being ubiquitinated and degraded by PPARγ, reduces fatty acid uptake and mitochondrial respiration, and inhibits the transcription of CD36 and FABP4. ST-CY14 inhibits the proliferation and migration of cancer cell MCF7 and MDA-MB-231. ST-CY14 inhibits tumor growth and bone metastasis in mouse models.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

ST-CY14 Chemical Structure

ST-CY14 Chemical Structure

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ST-CY14 Related Antibodies

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Nurr1/NR4A2 Nur77/NR4A1

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Description

ST-CY14 is an inhibitor for Nur77-PPARγ interaction with an EC50 of 3.15 μM, that binds to Nur77 (Kd=32 nM), blocks Nur77 from being ubiquitinated and degraded by PPARγ, reduces fatty acid uptake and mitochondrial respiration, and inhibits the transcription of CD36 and FABP4. ST-CY14 inhibits the proliferation and migration of cancer cell MCF7 and MDA-MB-231. ST-CY14 inhibits tumor growth and bone metastasis in mouse models[1].

Molecular Weight

3266.86

Formula

C139H237N57O31S2
Sequence

Cys-Glu-Gly-Cys-Lys-Gly-Phe-{S5}-Arg-Arg-Thr-{S5}-Arg-Tyr-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-NH2
Sequence Shortening

CEGCKGF-{S5}-RRT-{S5}-RYYGRKKRRQRRR-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ST-CY14 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ST-CY14Nuclear Hormone Receptor 4A/NR4AMitochondrial MetabolismNerve Growth Factor IB-like ReceptorMCF7MDA-MB-231BALB/c mouseInhibitorinhibitorinhibit

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