ST7710AA1

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ST7710AA1 (compound 1l) is a potent PARP-1 inhibitor with an IC₅₀ value of 0.07 µM. ST7710AA1 shows an antiproliferative activity. ST7710AA1 shows anticancer activity.

For research use only. We do not sell to patients.

ST7710AA1 Chemical Structure

CAS No. : 1542067-20-8

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View All Isoforms

PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

Biological Activity
Purity & Documentation
References
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Description

ST7710AA1 (compound 1l) is a potent PARP-1 inhibitor with an IC₅₀ value of 0.07 µM. ST7710AA1 shows an antiproliferative activity. ST7710AA1 shows anticancer activity^[1].

IC₅₀ & Target^[1]

PARP-1

0.07 μM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	2.9 μM Compound: 1l, ST7710AA1	Antiproliferative activity against human A2780 cells after 72 hrs by SRB assay Antiproliferative activity against human A2780 cells after 72 hrs by SRB assay	[PMID: 24398383]
CAPAN-1	IC₅₀	22.04 μM Compound: 1l, ST7710AA1	Antiproliferative activity against BRCA2 gene mutated human Capan1 cells after 72 hrs by SRB assay Antiproliferative activity against BRCA2 gene mutated human Capan1 cells after 72 hrs by SRB assay	[PMID: 24398383]
HCC1937	IC₅₀	19.43 μM Compound: 1l, ST7710AA1	Antiproliferative activity against BRCA1 gene mutated human HCC1937 cells after 72 hrs by SRB assay Antiproliferative activity against BRCA1 gene mutated human HCC1937 cells after 72 hrs by SRB assay	[PMID: 24398383]
HeLa	EC₅₀	400 nM Compound: 1l, ST7710AA1	Inhibition of PARP-1 in human HeLa cells assessed as decrease of H2O2-induced PARylation after 3 hrs by fluorescence assay Inhibition of PARP-1 in human HeLa cells assessed as decrease of H2O2-induced PARylation after 3 hrs by fluorescence assay	[PMID: 24398383]

In Vitro

ST7710AA1 (compound 1l) (0-200 µM; 72 h) shows antiproliferative with IC₅₀s of 19.43, 22.04 µM for HCC1937, Capan 1, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ST7710AA1 (100 mg/kg; i.p.; every 2 days for 2 weeks) shows antitumor activity in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

334.41

Formula

C₂₀H₂₂N₄O

CAS No.

1542067-20-8

SMILES

O=C(N1C=CC2=C1N=C(C=C2)C3=CC=C(C=C3)CN4CCCCC4)N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Cincinelli R, et al. 7-Azaindole-1-carboxamides as a new class of PARP-1 inhibitors. Bioorg Med Chem. 2014 Feb 1;22(3):1089-103. [Content Brief]

ST7710AA1 Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ST7710AA11542067-20-8PARPpoly ADP ribose polymeraseHCC1937Capan 1antiproliferativeanticancerInhibitorinhibitorinhibit

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