2. JAK/STAT Signaling Stem Cell/Wnt Apoptosis
  3. STAT Survivin Apoptosis
  4. STAT3-IN-38

STAT3-IN-38 (Compound 4m) is an inhibitor of STAT3 (KD of rhSTAT3: 45.33  µM). STAT3-IN-38 binds to the SH2 domain of STAT3 protein and suppresses the STAT3’s phosphorylation at site pTyr705 as well as its downstream genes (Survivin and Mcl-1). STAT3-IN-38 could block cell-cycle and induce Apoptosis in colorectal cancer cells.

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STAT3-IN-38 Chemical Structure

STAT3-IN-38 Chemical Structure

CAS No. : 3033049-16-7

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STAT3-IN-38 Related Antibodies

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Description

STAT3-IN-38 (Compound 4m) is an inhibitor of STAT3 (KD of rhSTAT3: 45.33  µM). STAT3-IN-38 binds to the SH2 domain of STAT3 protein and suppresses the STAT3’s phosphorylation at site pTyr705 as well as its downstream genes (Survivin and Mcl-1). STAT3-IN-38 could block cell-cycle and induce Apoptosis in colorectal cancer cells[1].

IC50 & Target

STAT3

45.33 μM (Kd)

In Vitro

STAT3-IN-38 (0.5-1 μM, 6 h) inhibits the phosphorylation of STAT3 and decreases levels of the STAT3 target proteins survivin and myeloid cell leukemia 1 (Mcl-1) in HCT116 cells[1].
STAT3-IN-38 (0.02-12.5 μM, 48 h) inhibits the proliferation of A549, HCT116, and HepG2 cells[1].
STAT3-IN-38 (1-5 μM, 48 h) induces apoptosis and cell cycle arrest in HCT116 cells[1].
STAT3-IN-38 (1-10 µM, 6 days) reduces the viability of human colorectal cancer organoids (CCOs)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

STAT3-IN-38 Related Antibodies

Cell Cycle Analysis[1]

Cell Line: HCT-116
Concentration: 1, 2.5, 5 μM
Incubation Time: 48 h
Result: Delayed cell cycle distribution, with a leading cell cycle arrest in G2/M phase at low concentrations and in S and G2/M phases at high concentrations.

Cell Cytotoxicity Assay[1]

Cell Line: A549、HCT-116、HepG2
Concentration: 0.02, 0.1, 0.5, 2.5, 12.5 μM
Incubation Time: 48 h
Result: Inhibited the proliferation of A549, HCT116, and HepG2 cells (IC50s = 0.93, 0.61, and 1.79 µM, respectively).

Western Blot Analysis[1]

Cell Line: HCT-116
Concentration: 0.5, 0.75, 1 μM
Incubation Time: 6 h
Result: Decreased the level of p-STAT3 at site pTyr705 in a concentration dependent manner, and the function was stronger than celastrol at 1.0 μM.
Down-regulated the level of Survivin and Mcl-1.
Molecular Weight

559.80

Formula

C35H45NO3S
CAS No.
SMILES

C[C@@]12[C@]([C@@]3([H])[C@@](CC1)(CC[C@](C)(C3)C(NCCC4=CC=CS4)=O)C)(CC[C@@]5(C2=CC=C6C5=CC(C(O)=C6C)=O)C)C
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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STAT3-IN-38 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

STAT3-IN-383033049-16-7STATSurvivinApoptosisAnti-tumourHCT-116A549HepG2Cell-cycleColorectal cancerOrganoidInhibitorinhibitorinhibit

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