2. Immunology/Inflammation
  3. STING
  4. STING agonist-12

STING agonist-12 (Compound 53) is a potent, orally active human STING activator with an EC50 of 185 nM.

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STING agonist-12 Chemical Structure

STING agonist-12 Chemical Structure

CAS No. : 2259624-71-8

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Based on 1 publication(s) in Google Scholar

STING agonist-12 Related Antibodies

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Description

STING agonist-12 (Compound 53) is a potent, orally active human STING activator with an EC50 of 185 nM[1].

IC50 & Target

EC50: 185 nM (STING)[1]
In Vitro

STING agonist-12 (Compound 53) (10 μM) shows excellent pan-polymorph activity across the panel of STING proteins (92%, 107% and 92% against R232, H232 and HAQ, respectively) in HEK293T cells[1].
STING agonist-12 is not active at mouse STING[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

STING agonist-12 Related Antibodies
In Vivo

STING agonist-12 (Compound 53) (5 mpk for i.v.; 10 mpk for p.o.) is well-absorbed with a short terminal half-life[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Balb/c mice (n=3)[1]
Dosage: 5 or 10 mpk
Administration: Lateral tail vein or oral gavage (Pharmacokinetic Analysis)
Result: Pharmacokinetic profile of STING agonist-12 (Compound 53) in mouse[1].
Route DOSE
(mpk)		 AUC
(ng/mL*h) 		T1/2
(h)		 Cmax
(ng/mL)		 Vd
(mL/kg)		 F
(%)
IV 5 1215 1.41 1867 2689 NA
PO 10 2090 NA 1723 NA 86
Molecular Weight

490.88

Formula

C25H19ClF4N2O2
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

ClC1=CC=CC(F)=C1CN2C3=C(C(C)(C2=O)C)C=CC(C(NCC4=C(C=C(C=C4F)F)F)=O)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (509.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0372 mL 10.1858 mL 20.3716 mL
5 mM 0.4074 mL 2.0372 mL 4.0743 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0372 mL 10.1858 mL 20.3716 mL 50.9289 mL
5 mM 0.4074 mL 2.0372 mL 4.0743 mL 10.1858 mL
10 mM 0.2037 mL 1.0186 mL 2.0372 mL 5.0929 mL
15 mM 0.1358 mL 0.6791 mL 1.3581 mL 3.3953 mL
20 mM 0.1019 mL 0.5093 mL 1.0186 mL 2.5464 mL
25 mM 0.0815 mL 0.4074 mL 0.8149 mL 2.0372 mL
30 mM 0.0679 mL 0.3395 mL 0.6791 mL 1.6976 mL
40 mM 0.0509 mL 0.2546 mL 0.5093 mL 1.2732 mL
50 mM 0.0407 mL 0.2037 mL 0.4074 mL 1.0186 mL
60 mM 0.0340 mL 0.1698 mL 0.3395 mL 0.8488 mL
80 mM 0.0255 mL 0.1273 mL 0.2546 mL 0.6366 mL
100 mM 0.0204 mL 0.1019 mL 0.2037 mL 0.5093 mL
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STING agonist-12 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

STING agonist-122259624-71-8STING agonist12STING agonist 12STINGStimulator of Interferon GenesTMEM173MITAERISMPYSHEK293TInhibitorinhibitorinhibit

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STING agonist-12
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