2. Immunology/Inflammation
  3. STING
  4. STING agonist-22

STING agonist-22 (CF501) is a potent non-nucleotide STING agonist. STING agonist-22 is a adjuvant by activating STING to induce the type I interferon (IFN-I) response and proinflammatory cytokine production. STING agonist-22 can be used as an adjuvant to boost the original protein vaccine, producing potent, broad, and long-term immune protection. STING agonist-22 can be used for SARS-CoV-2 variants and sarbecovirus diseases research.

For research use only. We do not sell to patients.

STING agonist-22 Chemical Structure

STING agonist-22 Chemical Structure

CAS No. : 2408723-12-4

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1 mg USD 350 In-stock
5 mg USD 940 In-stock
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Based on 1 publication(s) in Google Scholar

STING agonist-22 Related Antibodies

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Description

STING agonist-22 (CF501) is a potent non-nucleotide STING agonist. STING agonist-22 is a adjuvant by activating STING to induce the type I interferon (IFN-I) response and proinflammatory cytokine production. STING agonist-22 can be used as an adjuvant to boost the original protein vaccine, producing potent, broad, and long-term immune protection. STING agonist-22 can be used for SARS-CoV-2 variants and sarbecovirus diseases research[1].

In Vitro

STING agonist-22 (CF501) leads to rapid and robust activation of innate immune responses in THP-1 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

STING agonist-22 Related Antibodies
In Vivo

STING agonist-22 (CF501) robustly, but transiently, activates innate immunity with acceptable safety profile in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Balb/c mice (female, six weeks old)[1]
Dosage: 20, 75 μg
Administration: Intramuscular injection
Result: Although innate immunity was activated only transiently by CF501, it should be sufficient to stimulate the required humoral and cellular immune responses. The half-life of CF501 was 0.5 h and there was no detectable CF501 in the plasma after 2 h of the injection.
Molecular Weight

820.90

Formula

C40H48N14O6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NC(C1=CC2=C(N=C1)N(C/C=C/CN3C(NC(C4=CC(C)=NN4CC)=O)=NC5=C3C(OCCCN6CCOCC6)=CC(C(N)=O)=C5)C(NC(C7=CC(C)=NN7CC)=O)=N2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (121.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2182 mL 6.0909 mL 12.1818 mL
5 mM 0.2436 mL 1.2182 mL 2.4364 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2182 mL 6.0909 mL 12.1818 mL 30.4544 mL
5 mM 0.2436 mL 1.2182 mL 2.4364 mL 6.0909 mL
10 mM 0.1218 mL 0.6091 mL 1.2182 mL 3.0454 mL
15 mM 0.0812 mL 0.4061 mL 0.8121 mL 2.0303 mL
20 mM 0.0609 mL 0.3045 mL 0.6091 mL 1.5227 mL
25 mM 0.0487 mL 0.2436 mL 0.4873 mL 1.2182 mL
30 mM 0.0406 mL 0.2030 mL 0.4061 mL 1.0151 mL
40 mM 0.0305 mL 0.1523 mL 0.3045 mL 0.7614 mL
50 mM 0.0244 mL 0.1218 mL 0.2436 mL 0.6091 mL
60 mM 0.0203 mL 0.1015 mL 0.2030 mL 0.5076 mL
80 mM 0.0152 mL 0.0761 mL 0.1523 mL 0.3807 mL
100 mM 0.0122 mL 0.0609 mL 0.1218 mL 0.3045 mL
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STING agonist-22 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

STING agonist-222408723-12-4STING agonist22STING agonist 22STINGStimulator of Interferon GenesTMEM173MITAERISMPYSTHP-1 cellsSARS-CoV-2CF501RBD-FcHEK293T cellsHuh-7 cellsVero-E6 cellsInhibitorinhibitorinhibit

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STING agonist-22
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