STING antagonist 1

Cat. No.: HY-162664 Purity: 99.31%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

STING antagonist 1 (Compound 107) is the antagonist for STING with an IC₅₀ of 3.8 nM. STING antagonist 1 exhibits inhibitory efficacy in human whole blood, with IC₅₀ of 31 nM.

For research use only. We do not sell to patients.

STING antagonist 1 Chemical Structure

CAS No. : 3036981-21-9

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	Get quote
200 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Purity & Documentation
References
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Description

STING antagonist 1 (Compound 107) is the antagonist for STING with an IC₅₀ of 3.8 nM. STING antagonist 1 exhibits inhibitory efficacy in human whole blood, with IC₅₀ of 31 nM^[1].

Molecular Weight

519.62

Formula

C₃₁H₃₀FN₇

CAS No.

3036981-21-9

Appearance

Solid

Color

White to off-white

SMILES

F[C@H](C1=CC=CC=C1)CN2N=C3C=CC=C(C4=C(C5CC5)N(C)C(C6=CC7=CN(C)N=C7N=C6CC)=N4)C3=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (240.56 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9245 mL	9.6224 mL	19.2448 mL
5 mM	0.3849 mL	1.9245 mL	3.8490 mL
10 mM	0.1924 mL	0.9622 mL	1.9245 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.31%

Select Batch:

Data Sheet (272 KB) SDS (251 KB)

COA (255 KB) HNMR (275 KB) LCMS (96 KB)

Handling Instructions (2659 KB)

References

[1]. Hoffmann M, et al., Heterocyclic compounds as sting antagonists. WO2024089155A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9245 mL	9.6224 mL	19.2448 mL	48.1121 mL
	5 mM	0.3849 mL	1.9245 mL	3.8490 mL	9.6224 mL
	10 mM	0.1924 mL	0.9622 mL	1.9245 mL	4.8112 mL
	15 mM	0.1283 mL	0.6415 mL	1.2830 mL	3.2075 mL
	20 mM	0.0962 mL	0.4811 mL	0.9622 mL	2.4056 mL
	25 mM	0.0770 mL	0.3849 mL	0.7698 mL	1.9245 mL
	30 mM	0.0641 mL	0.3207 mL	0.6415 mL	1.6037 mL
	40 mM	0.0481 mL	0.2406 mL	0.4811 mL	1.2028 mL
	50 mM	0.0385 mL	0.1924 mL	0.3849 mL	0.9622 mL
	60 mM	0.0321 mL	0.1604 mL	0.3207 mL	0.8019 mL
	80 mM	0.0241 mL	0.1203 mL	0.2406 mL	0.6014 mL
	100 mM	0.0192 mL	0.0962 mL	0.1924 mL	0.4811 mL