2. Cell Cycle/DNA Damage PI3K/Akt/mTOR
  3. DNA-PK PI3K
  4. SU-11752

SU-11752 is an inhibitor for DNA-dependent protein kinase (DNA-PK) with an IC50 of 0.13 μM. SU-11752 inhibits PI3K p110γ kinase with IC50 of 1.1 μM. SU-11752 binds competitively for ATP-site in DNA-PK, results in inhibition of intracellular DNA double-strand break repair and increases the sensitivity of cells to radiotherapy.

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SU-11752 Chemical Structure

SU-11752 Chemical Structure

CAS No. : 688036-19-3

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SU-11752 Related Antibodies

Top Publications Citing Use of Products

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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Description

SU-11752 is an inhibitor for DNA-dependent protein kinase (DNA-PK) with an IC50 of 0.13 μM. SU-11752 inhibits PI3K p110γ kinase with IC50 of 1.1 μM. SU-11752 binds competitively for ATP-site in DNA-PK, results in inhibition of intracellular DNA double-strand break repair and increases the sensitivity of cells to radiotherapy[1].

IC50 & Target

DNA-PK

0.13 μM (IC50)

p110γ

1.1 μM (IC50)

Molecular Weight

493.57

Formula

C26H27N3O5S
CAS No.
SMILES

O=C(CCC1=C(NC(/C=C2C(NC3=C\2C=C(C=C3)S(=O)(NC4=CC=CC=C4)=O)=O)=C1CC)CC)O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SU-11752 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SU-11752688036-19-3SU11752SU 11752DNA-PKPI3KDNA-dependent protein kinasePhosphoinositide 3-kinaseradiotherapycompetitiveInhibitorinhibitorinhibit

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