1. GPCR/G Protein Neuronal Signaling
  2. Neurokinin Receptor
  3. Substance P (6-11)

Substance P (6-11) is the C-terminal hexapeptideamide of Substance P (Substance P (HY-P0201)). Substance P (6-11) binds to NK-1 tachykinin receptor. Substance P (6-11) shows depolarization of motoneurons and a hypotensive effect.

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Substance P (6-11) Chemical Structure

Substance P (6-11) Chemical Structure

CAS No. : 51165-07-2

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Description

Substance P (6-11) is the C-terminal hexapeptideamide of Substance P (Substance P (HY-P0201)). Substance P (6-11) binds to NK-1 tachykinin receptor. Substance P (6-11) shows depolarization of motoneurons and a hypotensive effect[1][2].

In Vitro

Substance P(6-11) stimulates [3H]-inositol monophosphate ([3H]-IP1) formation with an EC50 value 4 nM in rat urinary bladder[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Substance P (6-11) (0.1-10 nM) inhibits insulin and glucagon secretion from the rat pancreas in a dose-dependent manner. In the canine pancreas, by contrast, Substance P (6-11) (1-10 nM), potentiates the release of insulin, glucagon, and somatostatin[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

740.91

Formula

C36H52N8O7S

CAS No.
Sequence Shortening

QFFGLM-NH2

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Substance P (6-11)
Cat. No.:
HY-P3889
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