1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. Succinic-2,2,3,3-d4 acid

Succinic-2,2,3,3-d4 acid is the deuterium labeled Succinic acid. Succinic acid is an intermediate product of the tricarboxylic acid cycle, as well as one of fermentation products of anaerobic metabolism.

For research use only. We do not sell to patients.

Succinic-2,2,3,3-d<sub>4</sub> acid Chemical Structure

Succinic-2,2,3,3-d4 acid Chemical Structure

CAS No. : 14493-42-6

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100 mg USD 80 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Succinic-2,2,3,3-d4 acid:

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  • Biological Activity

  • Purity & Documentation

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Description

Succinic-2,2,3,3-d4 acid is the deuterium labeled Succinic acid. Succinic acid is an intermediate product of the tricarboxylic acid cycle, as well as one of fermentation products of anaerobic metabolism.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

122.11

Formula

C4H2D4O4

CAS No.
Unlabeled CAS

110-15-6

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)C([2H])([2H])C([2H])([2H])C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (818.93 mM; Need ultrasonic)

DMSO : 100 mg/mL (818.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 30 mg/mL (245.68 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 8.1893 mL 40.9467 mL 81.8934 mL
5 mM 1.6379 mL 8.1893 mL 16.3787 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥99.0%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / H2O / DMSO 1 mM 8.1893 mL 40.9467 mL 81.8934 mL 204.7334 mL
5 mM 1.6379 mL 8.1893 mL 16.3787 mL 40.9467 mL
10 mM 0.8189 mL 4.0947 mL 8.1893 mL 20.4733 mL
15 mM 0.5460 mL 2.7298 mL 5.4596 mL 13.6489 mL
20 mM 0.4095 mL 2.0473 mL 4.0947 mL 10.2367 mL
25 mM 0.3276 mL 1.6379 mL 3.2757 mL 8.1893 mL
30 mM 0.2730 mL 1.3649 mL 2.7298 mL 6.8244 mL
40 mM 0.2047 mL 1.0237 mL 2.0473 mL 5.1183 mL
50 mM 0.1638 mL 0.8189 mL 1.6379 mL 4.0947 mL
60 mM 0.1365 mL 0.6824 mL 1.3649 mL 3.4122 mL
80 mM 0.1024 mL 0.5118 mL 1.0237 mL 2.5592 mL
100 mM 0.0819 mL 0.4095 mL 0.8189 mL 2.0473 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Product Name:
Succinic-2,2,3,3-d4 acid
Cat. No.:
HY-N0420S1
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