2. Immunology/Inflammation
  3. Mucin
  4. Surzebiclimab

Surzebiclimab  (Synonyms: BGB-A425)

Cat. No.: HY-P99962 Purity: 95.00%
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Surzebiclimab (BGB-A425) is a humanized IgG1-variant monoclonal antibody against T-cell immunoglobulin and mucin-domain containing-3 (TIM-3). Surzebiclimab binds to the extracellular domain of human Tim-3 with high affinity (KD=0.36 nM) and specificity. Surzebiclimab can be used in research of cancer.

For research use only. We do not sell to patients.

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1 mg USD 350 In-stock
5 mg USD 910 In-stock
10 mg USD 1450 In-stock
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Based on 1 publication(s) in Google Scholar

Surzebiclimab Related Antibodies

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Description

Surzebiclimab (BGB-A425) is a humanized IgG1-variant monoclonal antibody against T-cell immunoglobulin and mucin-domain containing-3 (TIM-3). Surzebiclimab binds to the extracellular domain of human Tim-3 with high affinity (KD=0.36 nM) and specificity. Surzebiclimab can be used in research of cancer[1].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species

Humanized
In Vitro

Surzebiclimab (BGB-A425; 0.1-100 μg/mL) efficiently blocks the interactions between Tim-3 and PtdSer. Surzebiclimab enhances IFN-γ production of primary T cells and NK-mediated cytotoxicity against tumor cells[1].
Surzebiclimab augments T-cell response to allogeneic antigens either alone or in combination with an anti-PD-1 antibody BGB-A317. Surzebiclimab can also induce the internalization of Tim-3 receptor on cell surface[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Surzebiclimab Related Antibodies
In Vivo

Surzebiclimab (BGB-A425) in combination with BGB-A317 inhibits tumor growth in a mouse xenograft cancer model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Surzebiclimab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Purity & Documentation
References
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Surzebiclimab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SurzebiclimabBGB-A425Mucinhumanized monoclonal antibodyIFN-γprimary T cellsNK-mediated cytotoxicitycancerInhibitorinhibitorinhibit

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