2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR PDGFR VEGFR
  4. Sutetinib

Sutetinib is an orally active inhibitor for tyrosine kinase, that is associated with tumor growth and angiogenesis, such as VEGFR (Ki= 0.009 µM for VEGFR-1/2/3), PDGFR (Ki= 0.008 µM for PDGFR-α/β) and proto-oncogene cKIT. Sutetinib inhibits the proliferation, migration, and tubular structure formation of endothelial cells and fibroblasts, and exhibits board-spectrum antitumor efficacy in vitro and in vivo.

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Sutetinib Chemical Structure

Sutetinib Chemical Structure

CAS No. : 1259519-20-4

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Sutetinib Related Antibodies

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Description

Sutetinib is an orally active inhibitor for tyrosine kinase, that is associated with tumor growth and angiogenesis, such as VEGFR (Ki= 0.009 µM for VEGFR-1/2/3), PDGFR (Ki= 0.008 µM for PDGFR-α/β) and proto-oncogene cKIT. Sutetinib inhibits the proliferation, migration, and tubular structure formation of endothelial cells and fibroblasts, and exhibits board-spectrum antitumor efficacy in vitro and in vivo[1].

Molecular Weight

439.51

Formula

C26H25N5O2
CAS No.
SMILES

CCOC(C(NC(/C=C/CN(C)C)=O)=C1)=CC2=C1C(NC3=CC(C#C)=CC=C3)=C(C#N)C=N2
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Room temperature in continental US; may vary elsewhere.
Storage

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Purity & Documentation
References
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Sutetinib Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sutetinib1259519-20-4EGFRPDGFRVEGFREpidermal growth factor receptorErbB-1HER1Platelet-derived growth factor receptorVascular endothelial growth factor receptorcolon cancerbreast cancermelanomalung cancercolorectal cancerglioblastomaorally activeInhibitorinhibitorinhibit

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