2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. Suzetrigine

Suzetrigine  (Synonyms: VX-548)

Cat. No.: HY-148800 Purity: 99.91%
SDS COA Handling Instructions

Molarity Calculator

Suzetrigine (VX-548) is an orally active and highly selective NaV1.8 inhibitor that acts as an analgesic. Suzetrigine is also a blocker of sodium channel protein type 10 subunit alpha. Suzetrigine is promising for research of acute pain after abdominoplasty and bunionectomy.

For research use only. We do not sell to patients.

Suzetrigine Chemical Structure

Suzetrigine Chemical Structure

CAS No. : 2649467-58-1

Size Price Stock Quantity
1 mg USD 580 In-stock
5 mg USD 1450 In-stock
10 mg USD 2150 In-stock
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Suzetrigine Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Suzetrigine

View All Sodium Channel Isoform Specific Products:

View All Isoforms
Nav1.1 Nav1.2 Nav1.3 Nav1.4 Nav1.5 Nav1.6 Nav1.7 Nav1.8

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Suzetrigine (VX-548) is an orally active and highly selective NaV1.8 inhibitor that acts as an analgesic. Suzetrigine is also a blocker of sodium channel protein type 10 subunit alpha. Suzetrigine is promising for research of acute pain after abdominoplasty and bunionectomy[1][2][3][4][5].

In Vivo


Pharmacokinetic parameters of Suzetrigine in monkey plasma after oral and intravenous administrations[3]

Parameters AUC0-t (ng·h/mL) Cmax (ng/mL) Tmax (h) T1/2 (h) CL (mL/min/kg) Vd (L/kg) MRT0-t (h) F (%)
Intravenous (1 mg/kg, n = 3) 2843.2 ± 350.2 - - 4.6 ± 0.2 5.8 ± 0.6 2.3 ± 0.4 5.7 ± 0.2 71
Oral (2 mg/kg, n = 3) 4040.8 ± 212.5 533.3 ± 10.6 1 5.0 ± 0.9 7.2 ± 0.5 3.5 ± 0.6 7.6 ± 0.7

Pharmacokinetic parameters of Suzetrigine rats after intravenous administration at a single dose of 1 mg/kg[4]
Parameters AUC0-t (ng·h/mL) T1/2 (h) CL (mL/min/kg) Vss (L/kg) MRT0-t (h)
Female (n = 3) 1505.8 ± 47.3 3.7 ± 0.4 12.5 ± 0.8 5.0 ± 1.0 6.4 ± 0.3
Male (n = 3) 253.8 ± 6.3 1.9 ± 0.2 65.1 ± 1.7 7.2 ± 0.8 1.7 ± 0.2

Pharmacokinetic parameters of Suzetrigine rats after oral administration at a single dose of 2 mg/kg[4]
Parameters AUC0-t (ng·h/mL) T1/2 (h) Cmax (ng/mL) Tmax (h) F (%)
Female (n = 3) 2905.2 ± 98.6 4.9 ± 0.5 369.6 ± 62.2 0.5-1 96
Male (n = 3) 56.9 ± 18.5 2.5 ±0.2 31.7 ± 12.5 0.5-1 11

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

473.39

Formula

C21H20F5N3O4
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

NC(C1=CC(NC([C@H]2[C@H](C3=C(C(F)=C(C=C3)F)OC)[C@@H]([C@@](C)(O2)C(F)(F)F)C)=O)=CC=N1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (264.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1124 mL 10.5621 mL 21.1242 mL
5 mM 0.4225 mL 2.1124 mL 4.2248 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.91%

SDS (252 KB)

COA (253 KB) HNMR (291 KB) LCMS (94 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1124 mL 10.5621 mL 21.1242 mL 52.8106 mL
5 mM 0.4225 mL 2.1124 mL 4.2248 mL 10.5621 mL
10 mM 0.2112 mL 1.0562 mL 2.1124 mL 5.2811 mL
15 mM 0.1408 mL 0.7041 mL 1.4083 mL 3.5207 mL
20 mM 0.1056 mL 0.5281 mL 1.0562 mL 2.6405 mL
25 mM 0.0845 mL 0.4225 mL 0.8450 mL 2.1124 mL
30 mM 0.0704 mL 0.3521 mL 0.7041 mL 1.7604 mL
40 mM 0.0528 mL 0.2641 mL 0.5281 mL 1.3203 mL
50 mM 0.0422 mL 0.2112 mL 0.4225 mL 1.0562 mL
60 mM 0.0352 mL 0.1760 mL 0.3521 mL 0.8802 mL
80 mM 0.0264 mL 0.1320 mL 0.2641 mL 0.6601 mL
100 mM 0.0211 mL 0.1056 mL 0.2112 mL 0.5281 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Suzetrigine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Suzetrigine2649467-58-1VX-548VX548VX 548Sodium ChannelNa channelsNa+ channelsNaV1.8sodium channelblockerneurological diseaseInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Suzetrigine
Cat. No.:
HY-148800
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (252 KB) Français - FR (252 KB) Deutsch - DE (252 KB) Norwegian - NO (252 KB) Español - ES (252 KB) Swedish - SV (252 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.