t-Boc-N-amido-PEG5-acetic acid

Name: t-Boc-N-amido-PEG5-acetic acid
Brand: MedChemExpress
SKU: HY-W190962
Rating: 4.5 (1 reviews)

Cat. No.: HY-W190962 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

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BocNH-PEG5-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

t-Boc-N-amido-PEG5-acetic acid Chemical Structure

CAS No. : 890152-41-7

Size	Price	Stock	Quantity
25 mg	USD 25	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 35	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 44	In-stock	Estimated Time of Arrival: December 31
250 mg	USD 53	In-stock	Estimated Time of Arrival: December 31
1 g	USD 81	In-stock	Estimated Time of Arrival: December 31
5 g		Get quote
10 g		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

BocNH-PEG5-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1].

IC₅₀ & Target

PEGs

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

395.45

Formula

C₁₇H₃₃NO₉

CAS No.

890152-41-7

Appearance

Liquid (Density: 1.136±0.06 g/cm³)

Color

Colorless to light yellow

SMILES

O=C(NCCOCCOCCOCCOCCOCC(O)=O)OC(C)(C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (252.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5288 mL	12.6438 mL	25.2876 mL
5 mM	0.5058 mL	2.5288 mL	5.0575 mL
10 mM	0.2529 mL	1.2644 mL	2.5288 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (265 KB) SDS (393 KB)

COA (240 KB)

Handling Instructions (2659 KB)

References

[1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.5288 mL	12.6438 mL	25.2876 mL	63.2191 mL
	5 mM	0.5058 mL	2.5288 mL	5.0575 mL	12.6438 mL
	10 mM	0.2529 mL	1.2644 mL	2.5288 mL	6.3219 mL
	15 mM	0.1686 mL	0.8429 mL	1.6858 mL	4.2146 mL
	20 mM	0.1264 mL	0.6322 mL	1.2644 mL	3.1610 mL
	25 mM	0.1012 mL	0.5058 mL	1.0115 mL	2.5288 mL
	30 mM	0.0843 mL	0.4215 mL	0.8429 mL	2.1073 mL
	40 mM	0.0632 mL	0.3161 mL	0.6322 mL	1.5805 mL
	50 mM	0.0506 mL	0.2529 mL	0.5058 mL	1.2644 mL
	60 mM	0.0421 mL	0.2107 mL	0.4215 mL	1.0537 mL
	80 mM	0.0316 mL	0.1580 mL	0.3161 mL	0.7902 mL
	100 mM	0.0253 mL	0.1264 mL	0.2529 mL	0.6322 mL