TAN-67 dihydrobromide (Synonyms: SB-205607 dihydrobromide)

Cat. No.: HY-101317 Purity: ≥99.0%: FAQs
Data Sheet SDS COA Handling Instructions

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TAN-67 (SB-205607) dihydrobromide is a potent and selective nonpeptidic δ-opioid receptor agonist with a K_i value of 0.647 nM. TAN-67 dihydrobromide has neuroprotective effect. TAN-67 dihydrobromide can be used in research of ischemic stroke.

For research use only. We do not sell to patients.

TAN-67 dihydrobromide Chemical Structure

CAS No. : 1217628-73-3

Size	Price	Stock
5 mg	USD 600	Ask For Quote & Lead Time
10 mg	USD 960	Ask For Quote & Lead Time

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This product is a controlled substance and not for sale in your territory.

Other Forms of TAN-67 dihydrobromide:

TAN-67 Get quote

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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Opioid Receptor Isoform Specific Products:

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μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

δ Opioid Receptor/DOR

0.647 nM (Ki)

In Vitro

TAN-67 (SB-205607) dihydrobromide has high potency (EC₅₀=1.72 nM) for the inhibition of forskolin-stimulated cAMP accumulation at human delta-opioid receptors expressed by intact Chinese hamster ovary cells but low potency (EC₅₀=1520 nM) at human mu-opioid receptors expressed by intact B82 mouse fibroblast cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

TAN-67 (SB-205607; 1.5-4.5 mg/kg; i.v.; once) dihydrobromide reduces infarct volume in I/R-caused brain injury^[2].
TAN-67 (3 mg/kg; i.v.; once) dihydrobromide improves survival and neurobehavioral performance after I/R^[2].
TAN-67 (3 mg/kg; i.v.; once; adult C57BL/6J male mice) dihydrobromide increases both total APP and mature APP (APPm) levels and APP processing at an early time point (6 h)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Adult C57BL/6J male mice with I/R-caused brain injury^[2]
Dosage:	1.5, 3.0, and 4.5 mg/kg
Administration:	Intravenous injection; once
Result:	Reduced infarct volume in a dose-dependent manner.

Animal Model:	Adult C57BL/6J male mice with I/R-caused brain injury^[2]
Dosage:	3.0 mg/kg
Administration:	Intravenous injection; once
Result:	Had rapidly functional recovery than the vehicle-treated mice. Reduced neuronal cell death.

Animal Model:	Adult C57BL/6J male mice with transient middle cerebra artery occlusion (MCAO) ischemic stroke model^[2]
Dosage:	3.0 mg/kg
Administration:	Intravenous injection; once
Result:	Increased both total APP and mature APP (APPm) levels. Reduced β-secretase activity.

Molecular Weight

506.27

Formula

C₂₃H₂₆Br₂N₂O

CAS No.

1217628-73-3

Appearance

Solid

Color

White to off-white

SMILES

OC1=CC=CC([C@]23[C@@](CN(C)CC3)([H])CC4=CC5=CC=CC=C5N=C4C2)=C1.Br.Br

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 5 mg/mL (9.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9752 mL	9.8762 mL	19.7523 mL
5 mM	0.3950 mL	1.9752 mL	3.9505 mL
10 mM	---	---	---

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (276 KB) SDS (252 KB)

COA (250 KB) Elemental Analysis Report (108 KB)

Handling Instructions (2659 KB)

References

[1]. Knapp RJ, et, al. Properties of TAN-67, a nonpeptidic delta-opioid receptor agonist, at cloned human delta- and mu-opioid receptors. Eur J Pharmacol. 1995 Oct 15;291(2):129-34. [Content Brief]

[2]. Min JW, et, al. The non-peptidic δ-opioid receptor agonist Tan-67 mediates neuroprotection post-ischemically and is associated with altered amyloid precursor protein expression, maturation and processing in mice. J Neurochem. 2018 Feb;144(3):336-347. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9752 mL	9.8762 mL	19.7523 mL	49.3808 mL
DMSO	5 mM	0.3950 mL	1.9752 mL	3.9505 mL	9.8762 mL

TAN-67 dihydrobromide Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TAN-67 dihydrobromide1217628-73-3SB-205607 dihydrobromideOpioid Receptornonpeptidicneuroprotectiveischemic strokeCamphamster ovary cellsB82 mouse fibroblast cellsInhibitorinhibitorinhibit

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