2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. TAN-67 dihydrobromide

TAN-67 dihydrobromide  (Synonyms: SB-205607 dihydrobromide)

Cat. No.: HY-101317 Purity: ≥99.0%
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TAN-67 (SB-205607) dihydrobromide is a potent and selective nonpeptidic δ-opioid receptor agonist with a Ki value of 0.647 nM. TAN-67 dihydrobromide has neuroprotective effect. TAN-67 dihydrobromide can be used in research of ischemic stroke.

For research use only. We do not sell to patients.

TAN-67 dihydrobromide Chemical Structure

TAN-67 dihydrobromide Chemical Structure

CAS No. : 1217628-73-3

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Other Forms of TAN-67 dihydrobromide:

TAN-67 dihydrobromide Related Antibodies

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μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

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Description

TAN-67 (SB-205607) dihydrobromide is a potent and selective nonpeptidic δ-opioid receptor agonist with a Ki value of 0.647 nM. TAN-67 dihydrobromide has neuroprotective effect. TAN-67 dihydrobromide can be used in research of ischemic stroke[1][2].

IC50 & Target[1]

δ Opioid Receptor/DOR

0.647 nM (Ki)

In Vitro

TAN-67 (SB-205607) dihydrobromide has high potency (EC50=1.72 nM) for the inhibition of forskolin-stimulated cAMP accumulation at human delta-opioid receptors expressed by intact Chinese hamster ovary cells but low potency (EC50=1520 nM) at human mu-opioid receptors expressed by intact B82 mouse fibroblast cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TAN-67 dihydrobromide Related Antibodies
In Vivo

TAN-67 (SB-205607; 1.5-4.5 mg/kg; i.v.; once) dihydrobromide reduces infarct volume in I/R-caused brain injury[2].
TAN-67 (3 mg/kg; i.v.; once) dihydrobromide improves survival and neurobehavioral performance after I/R[2].
TAN-67 (3 mg/kg; i.v.; once; adult C57BL/6J male mice) dihydrobromide increases both total APP and mature APP (APPm) levels and APP processing at an early time point (6 h)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult C57BL/6J male mice with I/R-caused brain injury[2]
Dosage: 1.5, 3.0, and 4.5 mg/kg
Administration: Intravenous injection; once
Result: Reduced infarct volume in a dose-dependent manner.
Animal Model: Adult C57BL/6J male mice with I/R-caused brain injury[2]
Dosage: 3.0 mg/kg
Administration: Intravenous injection; once
Result: Had rapidly functional recovery than the vehicle-treated mice.
Reduced neuronal cell death.
Animal Model: Adult C57BL/6J male mice with transient middle cerebra artery occlusion (MCAO) ischemic stroke model[2]
Dosage: 3.0 mg/kg
Administration: Intravenous injection; once
Result: Increased both total APP and mature APP (APPm) levels.
Reduced β-secretase activity.
Molecular Weight

506.27

Formula

C23H26Br2N2O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC1=CC=CC([C@]23[C@@](CN(C)CC3)([H])CC4=CC5=CC=CC=C5N=C4C2)=C1.Br.Br
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (9.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9752 mL 9.8762 mL 19.7523 mL
5 mM 0.3950 mL 1.9752 mL 3.9505 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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V1

=
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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9752 mL 9.8762 mL 19.7523 mL 49.3808 mL
5 mM 0.3950 mL 1.9752 mL 3.9505 mL 9.8762 mL
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TAN-67 dihydrobromide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TAN-67 dihydrobromide1217628-73-3SB-205607 dihydrobromideOpioid Receptornonpeptidicneuroprotectiveischemic strokeCamphamster ovary cellsB82 mouse fibroblast cellsInhibitorinhibitorinhibit

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