2. Membrane Transporter/Ion Channel
  3. P-glycoprotein
  4. Tariquidar dimesylate

Tariquidar dimesylate  (Synonyms: XR9576 dimesylate)

Cat. No.: HY-10550B
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Tariquidar dimesylate (XR9576 dimesylate) is a P-glycoprotein (P-gp) inhibitor. Tariquidar dimesylate increases the concentration of the drug in the brain by binding to P-glycoprotein, preventing it from transporting the drug from inside to outside the brain. Tariquidar dimesylate can be used in the study of blood-brain barrier penetration and multidrug resistance.

For research use only. We do not sell to patients.

Tariquidar dimesylate Chemical Structure

Tariquidar dimesylate Chemical Structure

CAS No. : 625375-84-0

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Tariquidar dimesylate Related Antibodies

Top Publications Citing Use of Products

50 Publications Citing Use of MCE Tariquidar dimesylate

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    Tariquidar dimesylate purchased from MedChemExpress. Usage Cited in: Eur J Med Chem. 2017 Feb 15;127:586-598.  [Abstract]

    Fluorescence ratio values in K562/DOX cells incubated with Rhd 123 in the absence (control) and in the presence of Verapamil (ver.) and Tariquidar (tar.) tested at 3.0 μM and 1.0 μM concentrations respectively.

    Tariquidar dimesylate purchased from MedChemExpress. Usage Cited in: RSC Adv. 2016,6, 69083-69093.

    Western blot analysis on MCF-7/ADR cells after being treated by (A) control (without treatment), (B) free DOX, (C) CMC/CaCO3/DOX, (D) BCMC/CaCO3/DOX, (E) CMC/CaCO3/DOX/TQR, and (F) BCMC/CaCO3/DOX/TQR for 24 h.

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    Description

    Tariquidar dimesylate (XR9576 dimesylate) is a P-glycoprotein (P-gp) inhibitor. Tariquidar dimesylate increases the concentration of the drug in the brain by binding to P-glycoprotein, preventing it from transporting the drug from inside to outside the brain. Tariquidar dimesylate can be used in the study of blood-brain barrier penetration and multidrug resistance[1].

    Molecular Weight

    838.94

    Formula

    C40H46N4O12S2
    CAS No.
    SMILES

    O=C(NC1=CC(OC)=C(C=C1C(NC2=CC=C(C=C2)CCN3CC4=C(CC3)C=C(C(OC)=C4)OC)=O)OC)C5=CC6=CC=CC=C6N=C5.OS(=O)(C)=O.OS(=O)(C)=O
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    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    Tariquidar dimesylate Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Tariquidar dimesylate625375-84-0XR9576 dimesylateP-glycoproteinP-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243Blood-brain barrierMultidrug resistanceInhibitorinhibitorinhibit

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