2. Academic Validation
  3. Prolonged sleep deprivation induces a cytokine-storm-like syndrome in mammals

Prolonged sleep deprivation induces a cytokine-storm-like syndrome in mammals

  • Cell. 2023 Nov 14:S0092-8674(23)01176-5. doi: 10.1016/j.cell.2023.10.025.
Di Sang 1,  Keteng Lin 2,  Yini Yang 3,  Guangdi Ran 4,  Bohan Li 5,  Chen Chen 6,  Qi Li 4,  Yan Ma 4,  Lihui Lu 6,  Xi-Yang Cui 7,  Zhibo Liu 8,  Sheng-Qing Lv 9,  Minmin Luo 10,  Qinghua Liu 4,  Yulong Li 11,  Eric Erquan Zhang 12
Affiliations

Affiliations

  • 1 Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China; National Institute of Biological Sciences, Beijing, China.
  • 2 National Institute of Biological Sciences, Beijing, China; College of Biological Sciences, China Agricultural University, Beijing, China.
  • 3 Peking University School of Life Sciences, Beijing, China.
  • 4 National Institute of Biological Sciences, Beijing, China; Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, China.
  • 5 Peking-Tsinghua Center for Life Sciences, Beijing, China; Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.
  • 6 National Institute of Biological Sciences, Beijing, China.
  • 7 Beijing National Laboratory for Molecular Sciences, Radiochemistry and Radiation Chemistry Key Laboratory of Fundamental Science College of Chemistry and Molecular Engineering, Peking University, Beijing, China.
  • 8 Peking-Tsinghua Center for Life Sciences, Beijing, China; Beijing National Laboratory for Molecular Sciences, Radiochemistry and Radiation Chemistry Key Laboratory of Fundamental Science College of Chemistry and Molecular Engineering, Peking University, Beijing, China.
  • 9 Department of Neurosurgery, Xinqiao Hospital, Chongqing, China.
  • 10 National Institute of Biological Sciences, Beijing, China; School of Life Sciences, Tsinghua University, Beijing, China; Chinese Institute for Brain Research, Beijing, China.
  • 11 Peking University School of Life Sciences, Beijing, China; Peking-Tsinghua Center for Life Sciences, Beijing, China; State Key Laboratory of Membrane Biology, Beijing, China; PKU-IDG/McGovern Institute for Brain Research, Beijing, China.
  • 12 National Institute of Biological Sciences, Beijing, China; Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, China. Electronic address: zhangerquan@nibs.ac.cn.
PMID: 38016470 DOI: 10.1016/j.cell.2023.10.025
Abstract

Most Animals require sleep, and sleep loss induces serious pathophysiological consequences, including death. Previous experimental approaches for investigating sleep impacts in mice have been unable to persistently deprive Animals of both rapid eye movement sleep (REMS) and non-rapid eye movement sleep (NREMS). Here, we report a "curling prevention by water" paradigm wherein mice remain awake 96% of the time. After 4 days of exposure, mice exhibit severe inflammation, and approximately 80% die. Sleep deprivation increases levels of prostaglandin D2 (PGD2) in the brain, and we found that elevated PGD2 efflux across the blood-brain-barrier-mediated by ATP-binding cassette subfamily C4 transporter-induces both accumulation of circulating neutrophils and a cytokine-storm-like syndrome. Experimental disruption of the PGD2/DP1 axis dramatically reduced sleep-deprivation-induced inflammation. Thus, our study reveals that sleep-related changes in PGD2 in the central nervous system drive profound pathological consequences in the peripheral immune system.

Keywords

efflux; inflammation; prostaglandin D(2); sleep; sleep deprivation.

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