TASP0433864

Cat. No.: HY-116855 Purity: 99.9%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

TASP0433864 is a selective positive allosteric modulator (PAM) of metabotropic glutamate 2 (mGlu2) receptor with EC₅₀ values of 199 nM and 206 nM against human and rat mGlu2 receptors, respectively. TASP0433864 has antipsychotic activity.

For research use only. We do not sell to patients.

TASP0433864 Chemical Structure

CAS No. : 1431980-60-7

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5 mg		Ask For Quote & Lead Time

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This product is a controlled substance and not for sale in your territory.

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mGluR1 mGluR2 mGluR3 mGluR4 mGluR5 mGluR6 mGluR7 mGluR8 mGluR

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

hmGluR2

199 nM (EC₅₀)

rat mGluR2

206 nM (EC₅₀)

Molecular Weight

329.39

Formula

C₁₈H₂₃N₃O₃

CAS No.

1431980-60-7

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=C(C)N2C(O[C@H](COC3=CC=C(C(C)(C)C)C=C3)C2)=N1)N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 32.94 mg/mL (100.00 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.0359 mL	15.1796 mL	30.3591 mL
5 mM	0.6072 mL	3.0359 mL	6.0718 mL
10 mM	0.3036 mL	1.5180 mL	3.0359 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.9%

Select Batch:

Data Sheet (268 KB) SDS (251 KB)

COA (245 KB) Elemental Analysis Report (103 KB)

Handling Instructions (2659 KB)

References

[1]. Hiyoshi T, et al. Neurophysiologic and antipsychotic profiles of TASP0433864, a novel positive allosteric modulator of metabotropic glutamate 2 receptor. J Pharmacol Exp Ther. 2014 Dec;351(3):642-53. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.0359 mL	15.1796 mL	30.3591 mL	75.8979 mL
	5 mM	0.6072 mL	3.0359 mL	6.0718 mL	15.1796 mL
	10 mM	0.3036 mL	1.5180 mL	3.0359 mL	7.5898 mL
	15 mM	0.2024 mL	1.0120 mL	2.0239 mL	5.0599 mL
	20 mM	0.1518 mL	0.7590 mL	1.5180 mL	3.7949 mL
	25 mM	0.1214 mL	0.6072 mL	1.2144 mL	3.0359 mL
	30 mM	0.1012 mL	0.5060 mL	1.0120 mL	2.5299 mL
	40 mM	0.0759 mL	0.3795 mL	0.7590 mL	1.8974 mL
	50 mM	0.0607 mL	0.3036 mL	0.6072 mL	1.5180 mL
	60 mM	0.0506 mL	0.2530 mL	0.5060 mL	1.2650 mL
	80 mM	0.0379 mL	0.1897 mL	0.3795 mL	0.9487 mL

TASP0433864 Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TASP04338641431980-60-7TASP 0433864TASP-0433864mGluRMetabotropic glutamate receptorspositive allosteric modulatorantipsychotic activityInhibitorinhibitorinhibit

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