2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. TAT-GluA2 3Y

TAT-GluA2 3Y, an interference peptide, blocks long-term depression (LTD) at glutamatergic synapses by disrupting the endocytosis of AMPAR. TAT-GluA2 3Y can alleviate Pentobarbital-induced spatial memory deficits and synaptic depression.

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Custom Peptide Synthesis

TAT-GluA2 3Y Chemical Structure

TAT-GluA2 3Y Chemical Structure

CAS No. : 1404188-93-7

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10 mg USD 480 In-stock
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Based on 1 publication(s) in Google Scholar

TAT-GluA2 3Y Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE TAT-GluA2 3Y

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AMPA Receptor NMDA Receptor Kainate Receptor

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Description

TAT-GluA2 3Y, an interference peptide, blocks long-term depression (LTD) at glutamatergic synapses by disrupting the endocytosis of AMPAR. TAT-GluA2 3Y can alleviate Pentobarbital-induced spatial memory deficits and synaptic depression[1][2][3].

IC50 & Target

AMPAR[1]
Molecular Weight

2633.97

Formula

C115H185N43O29
CAS No.
Appearance

Solid

Color

White to off-white

Sequence Shortening

YGRKKRRQRRRYKEGYNVYG
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (37.97 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.3797 mL 1.8983 mL 3.7966 mL
5 mM 0.0759 mL 0.3797 mL 0.7593 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (37.97 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.3797 mL 1.8983 mL 3.7966 mL 9.4914 mL
5 mM 0.0759 mL 0.3797 mL 0.7593 mL 1.8983 mL
10 mM 0.0380 mL 0.1898 mL 0.3797 mL 0.9491 mL
15 mM 0.0253 mL 0.1266 mL 0.2531 mL 0.6328 mL
20 mM 0.0190 mL 0.0949 mL 0.1898 mL 0.4746 mL
25 mM 0.0152 mL 0.0759 mL 0.1519 mL 0.3797 mL
30 mM 0.0127 mL 0.0633 mL 0.1266 mL 0.3164 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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TAT-GluA2 3Y Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TAT-GluA2 3Y1404188-93-7iGluRIonotropic glutamate receptorsinterferenceLTDendocytosisAMPARspatialmemorydeficitssynapticdepressionInhibitorinhibitorinhibit

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