Tauro-β-muricholic acid sodium (Synonyms: T-βMCA sodium)

Name: Tauro-β-muricholic acid sodium
Brand: MedChemExpress
SKU: HY-135103
Rating: 4.5 (1 reviews)

Cat. No.: HY-135103 Purity: 98.60%: FAQs
Data Sheet SDS COA Handling Instructions

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Tauro-β-muricholic Acid sodium (T-βMCA sodium), a endogenous metabolite, is a competitive and reversible farnesoid X receptor (FXR) antagonist, with an IC₅₀ of 40 μM.

For research use only. We do not sell to patients.

Tauro-β-muricholic acid sodium Chemical Structure

CAS No. : 145022-92-0

Size	Price	Stock	Quantity
1 mg	USD 135	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 420	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 680	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1360	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 2180	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 3500	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

Other Forms of Tauro-β-muricholic acid sodium:

Tauro-β-muricholic acid-d₄ sodium Get quote
Tauro-β-muricholic acid Get quote

1 Publications Citing Use of MCE Tauro-β-muricholic acid sodium

•Cell Host Microbe. 2024 Feb 14;32(2):191-208.e9. [Abstract]

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Description

Tauro-β-muricholic Acid sodium (T-βMCA sodium), a endogenous metabolite, is a competitive and reversible farnesoid X receptor (FXR) antagonist, with an IC₅₀ of 40 μM^[1]^[2]^[3].

IC₅₀ & Target

IC50: 40 μM (FXR)^[1]

In Vitro

T-βMCA sodium inhibits FXR reporter activity in the CRC cell line HT29 (EC₅₀ ~10 μM)^[3].
T-βMCA sodium dose-dependently increases WNT signaling in HT29 and HCT116 cells^[3].
T-βMCA sodium induces proliferation and DNA damage in Lgr5⁺ cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

T-βMCA sodium (400 mg/kg; i.g.; twice a week; for 6 weeks) can effectively recapitulate the ability of HFD to promote CRC progression^[3].
T-βMCA sodium treatment also significantly increases levels of serum cytokines, including IFN-γ, IL-6, and IL-17^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	APCmin/+ mice^[3]
Dosage:	400 mg/kg
Administration:	Oral gavage; twice a week; for 6 weeks
Result:	Markedly decreased intestinal integrity and accelerated tumor growth in the intestine and colon.

Molecular Weight

537.68

Formula

C₂₆H₄₄NNaO₇S

CAS No.

145022-92-0

Appearance

Solid

Color

White to off-white

SMILES

C[C@@]([C@]1([H])[C@H](O)[C@@H]2O)(CC[C@@H](O)C1)[C@]3([H])[C@]2([H])[C@@](CC[C@]4([H])[C@H](C)CCC(NCCS(=O)(O[Na])=O)=O)([H])[C@]4(C)CC3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 10 mg/mL (18.60 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8598 mL	9.2992 mL	18.5984 mL
5 mM	0.3720 mL	1.8598 mL	3.7197 mL
10 mM	0.1860 mL	0.9299 mL	1.8598 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.60%

Select Batch:

Data Sheet (274 KB) SDS (252 KB)

COA (250 KB) HNMR (225 KB) RP-HPLC (265 KB) MS (72 KB)

Handling Instructions (2659 KB)

References

[1]. Sayin SI, et al. Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist. Cell Metab. 2013 Feb 5;17(2):225-35. [Content Brief]

[2]. Wahlström A, et al. Induction of farnesoid X receptor signaling in germ-free mice colonized with a human microbiota. J Lipid Res. 2017 Feb;58(2):412-419. [Content Brief]

[3]. Fu T, et al. FXR Regulates Intestinal Cancer Stem Cell Proliferation. Cell. 2019 Feb 21;176(5):1098-1112.e18. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.8598 mL	9.2992 mL	18.5984 mL	46.4961 mL
	5 mM	0.3720 mL	1.8598 mL	3.7197 mL	9.2992 mL
	10 mM	0.1860 mL	0.9299 mL	1.8598 mL	4.6496 mL
	15 mM	0.1240 mL	0.6199 mL	1.2399 mL	3.0997 mL

Tauro-β-muricholic acid sodium Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tauro-β-muricholic acid145022-92-0T-βMCAFXRNR1H4BileacidcolorectalcancerCRCInhibitorinhibitorinhibit

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Tauro-β-muricholic acid sodium (Synonyms: T-βMCA sodium)

Customer Review

Other Forms of Tauro-β-muricholic acid sodium:

Tauro-β-muricholic acid sodium Related Antibodies

1 Publications Citing Use of MCE Tauro-β-muricholic acid sodium

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Biological Activity

Purity & Documentation

References

Customer Review

Tauro-β-muricholic acid sodium Related Antibodies

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Complete Stock Solution Preparation Table

Tauro-β-muricholic acid sodium Related Classifications

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