TBAJ-876

Cat. No.: HY-128866: FAQs
Data Sheet Handling Instructions

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TBAJ-876 is the inhibitor of mycobacterium tuberculosis. TBAJ-876 is the analogue of the anti-tuberculosis agent Bedaquiline. TBAJ-876 has the potential for the research of tuberculosis.

For research use only. We do not sell to patients.

TBAJ-876 Chemical Structure

CAS No. : 2332841-25-3

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Other Forms of TBAJ-876:

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Biological Activity
Purity & Documentation
References
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Description

TBAJ-876 is the inhibitor of mycobacterium tuberculosis. TBAJ-876 is the analogue of the anti-tuberculosis agent Bedaquiline. TBAJ-876 has the potential for the research of tuberculosis^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
Vero	IC₅₀	> 10 μg/mL Compound: 3; TBAJ-876	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 72 hrs by MTS-PBS assay Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 72 hrs by MTS-PBS assay	[PMID: 31810890]
Vero	IC₅₀	> 10 μg/mL Compound: 46; TBAJ-876	Cytotoxicity against African green monkey Vero cells measured after 72 hrs by MTT assay Cytotoxicity against African green monkey Vero cells measured after 72 hrs by MTT assay	[PMID: 30803745]

Clinical Trial

Molecular Weight

657.55

Formula

C₃₁H₃₇BrN₄O₇

CAS No.

2332841-25-3

Appearance

Solid

Color

White to off-white

SMILES

COC1=NC(OC)=C(OC)C([C@H](C2=CC(C=C(Br)C=C3)=C3N=C2OC)[C@@](C4=CC(OC)=NC(OC)=C4)(O)CCN(C)C)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Sutherland HS, et al. Variations in the C-unit of bedaquiline provides analogues with improved biology and pharmacology. Bioorg Med Chem. 2020;28(1):115213. [Content Brief]

TBAJ-876 Related Classifications

Infection

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TBAJ-8762332841-25-3TBAJ876TBAJ 876Bacterialmycobacterium tuberculosisanaloguebedaquilineInhibitorinhibitorinhibit

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