TC-2559 difumarate

Name: TC-2559 difumarate
Brand: MedChemExpress
SKU: HY-136207
Rating: 4.5 (1 reviews)

Cat. No.: HY-136207 Purity: 98.4%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

TC-2559 idifumarate is a CNS-selective, orally active α4β2 subtype of nicotinic acetylcholine receptor (nAChR) partial agonist (EC₅₀=0.18 μM). TC-2559 difumarate shows selectivity for α4β2 over α2β4, α4β4 and α3β4 receptors, with EC₅₀s in the range of 10-30 µM. Antinociceptive effect.

For research use only. We do not sell to patients.

TC-2559 difumarate Chemical Structure

CAS No. : 2454492-41-0

Size	Price	Stock	Quantity
1 mg	USD 249	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 620	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 995	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of TC-2559 difumarate:

TC-2559 fumarate Get quote

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vivo

TC-2559 difumarate (1-10 mg/kg; i.p.) dose dependently reduces acute formalin-induced biphasic nociceptive responses in mice^[2].
TC-2559 difumarate (0.3-3 mg/kg; i.p.) dose dependently inhibits CCI-induced neuropathic pain in rats^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Adult male mice (body weight 15-30 g) (formalin test)^[2]
Dosage:	1, 3, 10 mg/kg
Administration:	I.p.
Result:	Dose dependently reduced both early and late phases of formalin induced nociceptive behavioral responses.

Animal Model:	Adult male SD rats (body weight 200-220 g) (chronic constriction injury (CCI))^[2]
Dosage:	0.3, 1, 3 mg/kg
Administration:	I.p.
Result:	Significantly reversed CCI induced the paw withdrawal threshold decreases.

Molecular Weight

438.43

Formula

C₂₀H₂₆N₂O₉

CAS No.

2454492-41-0

Appearance

Solid

Color

White to off-white

SMILES

CCOC1=CN=CC(/C=C/CCNC)=C1.O=C(/C=C/C(O)=O)O.O=C(/C=C/C(O)=O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 43.84 mg/mL (99.99 mM; Need ultrasonic and warming)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2809 mL	11.4043 mL	22.8087 mL
5 mM	0.4562 mL	2.2809 mL	4.5617 mL
10 mM	0.2281 mL	1.1404 mL	2.2809 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 98.4%

Select Batch:

Data Sheet (270 KB) SDS (252 KB)

COA (244 KB) Elemental Analysis Report (103 KB)

Handling Instructions (2659 KB)

References

[1]. Bencherif M, et al. TC-2559: a novel orally active ligand selective at neuronal acetylcholine receptors. Eur J Pharmacol. 2000;409(1):45-55. [Content Brief]

[2]. Cheng LZ, et al. Enhanced inhibitory synaptic transmission in the spinal dorsal horn mediates antinociceptive effects of TC-2559. Mol Pain. 2011;7:56. Published 2011 Aug 4. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	2.2809 mL	11.4043 mL	22.8087 mL	57.0216 mL
	5 mM	0.4562 mL	2.2809 mL	4.5617 mL	11.4043 mL
	10 mM	0.2281 mL	1.1404 mL	2.2809 mL	5.7022 mL
	15 mM	0.1521 mL	0.7603 mL	1.5206 mL	3.8014 mL
	20 mM	0.1140 mL	0.5702 mL	1.1404 mL	2.8511 mL
	25 mM	0.0912 mL	0.4562 mL	0.9123 mL	2.2809 mL
	30 mM	0.0760 mL	0.3801 mL	0.7603 mL	1.9007 mL
	40 mM	0.0570 mL	0.2851 mL	0.5702 mL	1.4255 mL
	50 mM	0.0456 mL	0.2281 mL	0.4562 mL	1.1404 mL
	60 mM	0.0380 mL	0.1901 mL	0.3801 mL	0.9504 mL
	80 mM	0.0285 mL	0.1426 mL	0.2851 mL	0.7128 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.