TCEP-d₁₆ hydrochloride

Name: TCEP-d 16 hydrochloride
Brand: MedChemExpress
SKU: HY-W011500S
Rating: 4.5 (1 reviews)

Cat. No.: HY-W011500S Purity: ≥97.0%: FAQs
Data Sheet SDS COA Handling Instructions

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TCEP-d₁₆ (hydrochloride) is the deuterium labeled TCEP hydrochloride[1]. TCEP hydrochloride (Tris(2-carboxyethyl)phosphine hydrochloride) is a non-thiol reducing agent that is more stable and produces a faster S-S reductive reaction than other chemical reductants. TCEP hydrochloride is a trialkylphosphine, selectively reduces protein disuldes without altering the properties or interacting with thiol-directed agents in the reaction mixture. TCEP hydrochloride is also a commonly used reducing agent in the DNA/AuNP chemistry[2][3][4][5].

For research use only. We do not sell to patients.

TCEP-d<sub>16</sub> hydrochloride Chemical Structure

TCEP-d₁₆ hydrochloride Chemical Structure

CAS No. : 1174025-33-2

Size	Price	Stock	Quantity
1 mg	USD 110	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 280	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 450	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of TCEP-d₁₆ hydrochloride:

TCEP hydrochloride Get quote

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Biological Activity
Purity & Documentation
References
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Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

302.75

Formula

C₉D₁₆ClO₆P

CAS No.

1174025-33-2

Unlabeled CAS

51805-45-9

Appearance

Solid

Color

White to off-white

SMILES

[2H]OC(C([2H])([2H])C([2H])([2H])P(C([2H])([2H])C([2H])([2H])C(O[2H])=O)C([2H])([2H])C([2H])([2H])C(O[2H])=O)=O.Cl[2H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (330.31 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3031 mL	16.5153 mL	33.0306 mL
5 mM	0.6606 mL	3.3031 mL	6.6061 mL
10 mM	0.3303 mL	1.6515 mL	3.3031 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥97.0%

Select Batch:

Data Sheet (281 KB) SDS (251 KB)

COA (259 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]

[2]. Dieguez-Acuña FJ, et al. Inhibition of NF-kappaB-DNA binding by mercuric ion: utility of the non-thiol reductant, tris(2-carboxyethyl)phosphine hydrochloride (TCEP), on detection of impaired NF-kappaB-DNA binding by thiol-directed agents. Toxicol In Vitro. 2000 Feb;14(1):7-16. [Content Brief]

[3]. Duchardt F, et al. A cell-penetrating peptide derived from human lactoferrin with conformation-dependent uptake efficiency. J Biol Chem. 2009 Dec 25284(52):36099-108. [Content Brief]

[4]. Sequeira MA, et al. Modulating amyloid fibrillation in a minimalist model peptide by intermolecular disulfide chemical reduction. Phys Chem Chem Phys. 2019 Jun 521(22):11916-11923. [Content Brief]

[5]. Wu R, et al. Effects of Small Molecules on DNA Adsorption by Gold Nanoparticles and a Case Study of Tris(2-carboxyethyl)phosphine (TCEP). Langmuir. 2019 Oct 1535(41):13461-13468. [Content Brief]

[6]. Han JC, Han GY. A procedure for quantitative determination of tris(2-carboxyethyl)phosphine, an odorless reducing agent more stable and effective than dithiothreitol. Anal Biochem. 1994220(1):5-10. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.3031 mL	16.5153 mL	33.0306 mL	82.5764 mL
	5 mM	0.6606 mL	3.3031 mL	6.6061 mL	16.5153 mL
	10 mM	0.3303 mL	1.6515 mL	3.3031 mL	8.2576 mL
	15 mM	0.2202 mL	1.1010 mL	2.2020 mL	5.5051 mL
	20 mM	0.1652 mL	0.8258 mL	1.6515 mL	4.1288 mL
	25 mM	0.1321 mL	0.6606 mL	1.3212 mL	3.3031 mL
	30 mM	0.1101 mL	0.5505 mL	1.1010 mL	2.7525 mL
	40 mM	0.0826 mL	0.4129 mL	0.8258 mL	2.0644 mL
	50 mM	0.0661 mL	0.3303 mL	0.6606 mL	1.6515 mL
	60 mM	0.0551 mL	0.2753 mL	0.5505 mL	1.3763 mL
	80 mM	0.0413 mL	0.2064 mL	0.4129 mL	1.0322 mL
	100 mM	0.0330 mL	0.1652 mL	0.3303 mL	0.8258 mL