2. PROTAC
  3. PROTAC Linkers
  4. TCO-NHS ester

TCO-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. TCO-NHS ester is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

For research use only. We do not sell to patients.

TCO-NHS ester Chemical Structure

TCO-NHS ester Chemical Structure

CAS No. : 1191901-33-3

Size Price Stock Quantity
25 mg USD 270 In-stock
50 mg USD 432 In-stock
100 mg USD 692 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

TCO-NHS ester Related Antibodies

Top Publications Citing Use of Products

View All PROTAC Linkers Isoform Specific Products:

View All Isoforms
PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

TCO-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. TCO-NHS ester is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

IC50 & Target

Alkyl/ether

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TCO-NHS ester Related Antibodies
Molecular Weight

267.28

Formula

C13H17NO5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(OC1CC/C=C/CCC1)ON2C(CCC2=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (374.14 mM; ultrasonic and warming and heat to 52°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7414 mL 18.7069 mL 37.4138 mL
5 mM 0.7483 mL 3.7414 mL 7.4828 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥95.0%

SDS (393 KB)

COA (255 KB) HNMR (264 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.7414 mL 18.7069 mL 37.4138 mL 93.5345 mL
5 mM 0.7483 mL 3.7414 mL 7.4828 mL 18.7069 mL
10 mM 0.3741 mL 1.8707 mL 3.7414 mL 9.3535 mL
15 mM 0.2494 mL 1.2471 mL 2.4943 mL 6.2356 mL
20 mM 0.1871 mL 0.9353 mL 1.8707 mL 4.6767 mL
25 mM 0.1497 mL 0.7483 mL 1.4966 mL 3.7414 mL
30 mM 0.1247 mL 0.6236 mL 1.2471 mL 3.1178 mL
40 mM 0.0935 mL 0.4677 mL 0.9353 mL 2.3384 mL
50 mM 0.0748 mL 0.3741 mL 0.7483 mL 1.8707 mL
60 mM 0.0624 mL 0.3118 mL 0.6236 mL 1.5589 mL
80 mM 0.0468 mL 0.2338 mL 0.4677 mL 1.1692 mL
100 mM 0.0374 mL 0.1871 mL 0.3741 mL 0.9353 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

TCO-NHS ester Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TCO-NHS ester1191901-33-3PROTAC LinkersInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
TCO-NHS ester
Cat. No.:
HY-141165
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (393 KB) Français - FR (393 KB) Deutsch - DE (393 KB) Norwegian - NO (393 KB) Español - ES (393 KB) Swedish - SV (393 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.