2. PROTAC
  3. PROTAC Linkers
  4. TCO-PEG3-acid

TCO-PEG3-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. TCO-PEG3-acid is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

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TCO-PEG3-acid Chemical Structure

TCO-PEG3-acid Chemical Structure

CAS No. : 2141981-86-2

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5 mg USD 110 In-stock
10 mg USD 180 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of TCO-PEG3-acid:

TCO-PEG3-acid Related Antibodies

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Description

TCO-PEG3-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. TCO-PEG3-acid is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

IC50 & Target[1]

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TCO-PEG3-acid Related Antibodies
Molecular Weight

373.44

Formula

C18H31NO7
CAS No.
Appearance

Oil

Color

Colorless to light yellow

SMILES

O=C(OC1CC/C=C\CCC1)NCCOCCOCCOCCC(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (669.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6778 mL 13.3890 mL 26.7781 mL
5 mM 0.5356 mL 2.6778 mL 5.3556 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6778 mL 13.3890 mL 26.7781 mL 66.9452 mL
5 mM 0.5356 mL 2.6778 mL 5.3556 mL 13.3890 mL
10 mM 0.2678 mL 1.3389 mL 2.6778 mL 6.6945 mL
15 mM 0.1785 mL 0.8926 mL 1.7852 mL 4.4630 mL
20 mM 0.1339 mL 0.6695 mL 1.3389 mL 3.3473 mL
25 mM 0.1071 mL 0.5356 mL 1.0711 mL 2.6778 mL
30 mM 0.0893 mL 0.4463 mL 0.8926 mL 2.2315 mL
40 mM 0.0669 mL 0.3347 mL 0.6695 mL 1.6736 mL
50 mM 0.0536 mL 0.2678 mL 0.5356 mL 1.3389 mL
60 mM 0.0446 mL 0.2232 mL 0.4463 mL 1.1158 mL
80 mM 0.0335 mL 0.1674 mL 0.3347 mL 0.8368 mL
100 mM 0.0268 mL 0.1339 mL 0.2678 mL 0.6695 mL
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TCO-PEG3-acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TCO-PEG3-acid2141981-86-2PROTAC LinkersPEGPROTAClinkerE3ubiquitinligaseproteinInhibitorinhibitorinhibit

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