2. Antibody-drug Conjugate/ADC Related PROTAC
  3. ADC Linker PROTAC Linkers
  4. (E/Z)-TCO-PEG4-NHS ester

(E/Z)-TCO-PEG4-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. (E/Z)-TCO-PEG4-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). (E/Z)-TCO-PEG4-NHS ester is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

For research use only. We do not sell to patients.

(E/Z)-TCO-PEG4-NHS ester Chemical Structure

(E/Z)-TCO-PEG4-NHS ester Chemical Structure

CAS No. : 1613439-69-2

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5 mg USD 77 Ask For Quote & Lead Time
10 mg USD 120 Ask For Quote & Lead Time
25 mg USD 240 Ask For Quote & Lead Time
50 mg USD 380 Ask For Quote & Lead Time
100 mg USD 610 Ask For Quote & Lead Time

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Other Forms of (E/Z)-TCO-PEG4-NHS ester:

(E/Z)-TCO-PEG4-NHS ester Related Antibodies

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Description

(E/Z)-TCO-PEG4-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. (E/Z)-TCO-PEG4-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. (E/Z)-TCO-PEG4-NHS ester is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

IC50 & Target[1]

Cleavable Linker

 

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(E/Z)-TCO-PEG4-NHS ester Related Antibodies
Molecular Weight

514.57

Formula

C24H38N2O10
CAS No.
Appearance

Oil

Color

Colorless to light yellow

SMILES

O=C(OC1CC/C=C\CCC1)NCCOCCOCCOCCOCCC(ON2C(CCC2=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (97.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9434 mL 9.7169 mL 19.4337 mL
5 mM 0.3887 mL 1.9434 mL 3.8867 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.58%

SDS (393 KB)

COA (242 KB) LCMS (188 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9434 mL 9.7169 mL 19.4337 mL 48.5843 mL
5 mM 0.3887 mL 1.9434 mL 3.8867 mL 9.7169 mL
10 mM 0.1943 mL 0.9717 mL 1.9434 mL 4.8584 mL
15 mM 0.1296 mL 0.6478 mL 1.2956 mL 3.2390 mL
20 mM 0.0972 mL 0.4858 mL 0.9717 mL 2.4292 mL
25 mM 0.0777 mL 0.3887 mL 0.7773 mL 1.9434 mL
30 mM 0.0648 mL 0.3239 mL 0.6478 mL 1.6195 mL
40 mM 0.0486 mL 0.2429 mL 0.4858 mL 1.2146 mL
50 mM 0.0389 mL 0.1943 mL 0.3887 mL 0.9717 mL
60 mM 0.0324 mL 0.1619 mL 0.3239 mL 0.8097 mL
80 mM 0.0243 mL 0.1215 mL 0.2429 mL 0.6073 mL
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(E/Z)-TCO-PEG4-NHS ester Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(E/Z)-TCO-PEG4-NHS ester1613439-69-2ADC LinkerPROTAC LinkersAntibody-drug conjugates linkercleavableADCantibody-drugconjugatesInhibitorinhibitorinhibit

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