TCS2002

Cat. No.: HY-10096 Purity: 99.8%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

TCS2002 (Compound 9b) is a highly selective, orally bioavailable and potent GSK-3β inhibitor with the IC₅₀ of 35 nM. TCS2002 shows good pharmacokinetic profiles including favorable BBB penetration. TCS2002 can be used for the research of Alzheimer’s disease.

For research use only. We do not sell to patients.

TCS2002 Chemical Structure

CAS No. : 1005201-24-0

Size	Price	Stock
5 mg	USD 408	Ask For Quote & Lead Time
10 mg	USD 653	Ask For Quote & Lead Time

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

GSK-3

35 nM (IC₅₀)

In Vivo

TCS2002 (Compound 9b) (1-3 mg/kg;1-24 hours; GS rats andC57BL/6N mice) exhibits good pharmacokinetic profiles and favor able BBB permeability with AUC_0-24h value is 734 ng?h/g and K_p value (ratio of brain and plasma) is 1.6^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

IGS rats (male, 8 weeks old)^[1]

Dosage:

1 and 3mg/kg

Administration:

Intravenous injection and oral administration;for 1, 2, 4, 8, 24 hours.

Result:

1.19

comp	(S)-9b	(S)-9c
V_DSS,iv (mL/kg)	1134	1650
CL_total,iv (mL/min/kg)	27.4	28.4
C_max,po (ng/mL)	396.9	289.6
AUC_{0-24 h,po} (ng·h/mL)	1380.6	1229.1
MRT_po (h)	2.19	3.03
F^d (%)	72.8	65.5

Molecular Weight

338.38

Formula

C₁₈H₁₄N₂O₃S

CAS No.

1005201-24-0

Appearance

Solid

Color

White to off-white

SMILES

O=S(C)C1=CC=C(C=C1)C2=COC3=CC=C(C4=NN=C(C)O4)C=C23

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 34 mg/mL (100.48 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9553 mL	14.7763 mL	29.5526 mL
5 mM	0.5911 mL	2.9553 mL	5.9105 mL
10 mM	0.2955 mL	1.4776 mL	2.9553 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.8%

Select Batch:

Data Sheet (280 KB) SDS (393 KB)

COA (257 KB) Elemental Analysis Report (115 KB)

Handling Instructions (2659 KB)

References

[1]. Morihisa Saitoh, et al. 2-{3-[4-(Alkylsulfinyl)phenyl]-1-benzofuran-5-yl}-5-methyl-1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3beta with good brain permeability. J Med Chem. 2009 Oct 22;52(20):6270-86. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.9553 mL	14.7763 mL	29.5526 mL	73.8814 mL
	5 mM	0.5911 mL	2.9553 mL	5.9105 mL	14.7763 mL
	10 mM	0.2955 mL	1.4776 mL	2.9553 mL	7.3881 mL
	15 mM	0.1970 mL	0.9851 mL	1.9702 mL	4.9254 mL
	20 mM	0.1478 mL	0.7388 mL	1.4776 mL	3.6941 mL
	25 mM	0.1182 mL	0.5911 mL	1.1821 mL	2.9553 mL
	30 mM	0.0985 mL	0.4925 mL	0.9851 mL	2.4627 mL
	40 mM	0.0739 mL	0.3694 mL	0.7388 mL	1.8470 mL
	50 mM	0.0591 mL	0.2955 mL	0.5911 mL	1.4776 mL
	60 mM	0.0493 mL	0.2463 mL	0.4925 mL	1.2314 mL
	80 mM	0.0369 mL	0.1847 mL	0.3694 mL	0.9235 mL
	100 mM	0.0296 mL	0.1478 mL	0.2955 mL	0.7388 mL

TCS2002 Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TCS20021005201-24-0TCS 2002TCS-2002GSK-3Glycogen synthase kinase-3Glycogen synthase kinase 3orally bioavailableGSK-3β inhibitorgood pharmacokinetic profileBBB penetrationAlzheimer diseaseInhibitorinhibitorinhibit

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