2. Metabolic Enzyme/Protease
  3. Phosphatase
  4. Tegeprotafib

Tegeprotafib  (Synonyms: PTPN2/1-IN-1)

Cat. No.: HY-153446 Purity: 98.12%
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Tegeprotafib (PTPN2/1-IN-1) (Compound 124) is an orally active PTPN1 and PTPN2 inhibitor with IC50s of 4.4 nM and 1-10 nM against PTPN2 and PTP1B, respectively.

For research use only. We do not sell to patients.

Tegeprotafib Chemical Structure

Tegeprotafib Chemical Structure

CAS No. : 2407610-46-0

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1 mg USD 680 In-stock
5 mg USD 1680 In-stock
10 mg USD 2680 In-stock
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Based on 1 publication(s) in Google Scholar

Tegeprotafib Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

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Description

Tegeprotafib (PTPN2/1-IN-1) (Compound 124) is an orally active PTPN1 and PTPN2 inhibitor with IC50s of 4.4 nM and 1-10 nM against PTPN2 and PTP1B, respectively[1].

IC50 & Target

IC50: 4.4 nM (PTPN2), 1-10 nM (PTP1B)[1]
In Vitro

Tegeprotafib (Compound 124; 5 days) inhibits IFNγ (0.5 ng/mL) induced B16F10 cellular growth with a percent growth inhibition of 60-90% at 33 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tegeprotafib Related Antibodies
In Vivo

Tegeprotafib (Compound 124; 300 mg/kg; oral; BID for 21 days) shows antitumor activity in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female C57B1/6 mice, MC-38 tumor model[1]
Dosage: 300 mg/kg/dose
Administration: Oral, twice a day (BID) at 7am and 5pm for 21 days
Result: Within 7-10 days of treatment, apparent tumor stasis and shrinkage was observed. 50% of mice achieved complete cures, and an overall TGIMEX was 75%. The frequency of functional, granzyme B (GzB) producing cells within the cytotoxic CD8+ T population in the spleen was 2.9-fold increased over vehicle control treated animals. Increased IP10 levels in plasma.
Molecular Weight

326.30

Formula

C13H11FN2O5S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1NS(=O)(N(C1)C2=C(F)C3=CC(OC)=CC=C3C=C2O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (306.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0647 mL 15.3233 mL 30.6466 mL
5 mM 0.6129 mL 3.0647 mL 6.1293 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

V1

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0647 mL 15.3233 mL 30.6466 mL 76.6166 mL
5 mM 0.6129 mL 3.0647 mL 6.1293 mL 15.3233 mL
10 mM 0.3065 mL 1.5323 mL 3.0647 mL 7.6617 mL
15 mM 0.2043 mL 1.0216 mL 2.0431 mL 5.1078 mL
20 mM 0.1532 mL 0.7662 mL 1.5323 mL 3.8308 mL
25 mM 0.1226 mL 0.6129 mL 1.2259 mL 3.0647 mL
30 mM 0.1022 mL 0.5108 mL 1.0216 mL 2.5539 mL
40 mM 0.0766 mL 0.3831 mL 0.7662 mL 1.9154 mL
50 mM 0.0613 mL 0.3065 mL 0.6129 mL 1.5323 mL
60 mM 0.0511 mL 0.2554 mL 0.5108 mL 1.2769 mL
80 mM 0.0383 mL 0.1915 mL 0.3831 mL 0.9577 mL
100 mM 0.0306 mL 0.1532 mL 0.3065 mL 0.7662 mL
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Tegeprotafib Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tegeprotafib2407610-46-0PTPN2/1-IN-1PhosphataseMC-38C57B1/6IFNγB16F10Inhibitorinhibitorinhibit

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