Tenofovir diphosphate triethylamine  (Synonyms: TFV-DP triethylamine)

Tenofovir diphosphate triethylamine (TFV-DP triethylamine) is a competitive DNA polymerases inhibitor (with respect to dATP) and a substrate of HIV type 1 (HIV-1) reverse transcriptase (RT)^[1].

Tenofovir diphosphate acts as an inhibitor of DNA pol. Tenofovir-diphosphate is a weak inhibitor of DNA polymerases (pol) α, δ, and ɛ, with values for the K_i for PMPApp (^PMPAppK_i) relative to the K_m for dATP (^dATPKm) of 10.2, 10.2, and 15.6, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

548.36

C₁₅H₃₁N₆O₁₀P₃

2122333-63-3

Solid

Light yellow to yellow

C[C@@H](OC[P](O[P](O[P](O)(O)=O)(O)=O)(O)=O)CN1C2=NC=NC(N)=C2N=C1.CCN(CC)CC

Room temperature in continental US; may vary elsewhere.

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

• [1]. Gabriel Birkus, et al. Tenofovir Diphosphate Is a Poor Substrate and a Weak Inhibitor of Rat DNA Polymerases Alpha, Delta, and epsilon. Antimicrob Agents Chemother. 2002 May;46(5):1610-3.  [Content Brief]