2. Membrane Transporter/Ion Channel Autophagy
  3. CFTR Autophagy
  4. Tezacaftor-d4

Tezacaftor-d4  (Synonyms: VX-661-d4)

Cat. No.: HY-15448S Purity: ≥97.0%
COA Handling Instructions

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Tezacaftor-d4 (VX-661-d4) is the deuterium-labeled Tezacaftor (HY-15448), a F508del CFTR corrector. Tezacaftor helps CFTR protein reach the cell surface.

For research use only. We do not sell to patients.

Tezacaftor-d<sub>4</sub> Chemical Structure

Tezacaftor-d4 Chemical Structure

CAS No. : 1961280-24-9

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Based on 1 publication(s) in Google Scholar

Other Forms of Tezacaftor-d4:

Tezacaftor-d4 Related Antibodies

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Description

Tezacaftor-d4 (VX-661-d4) is the deuterium-labeled Tezacaftor (HY-15448), a F508del CFTR corrector. Tezacaftor helps CFTR protein reach the cell surface[1][2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
However, Ivacaftor (VX-770, HY-13017), a CFTR potentiator, helps to prolong the opening time of cell surface CFTR protein channels. Tezacaftor combining with Ivacaftor, shows potent efficacy against cystic fibrosis and diseases with homozygous for the CFTR Phe508del mutation. Moreover, Elexacaftor (VX-445, HY-111772) is also a CFTR corrector. Elexacaftor-Tezacaftor-Ivacaftor aims at with cystic fibrosis (CF) with at least one Phe508del mutation, often avoids the indication for lung transplantation[3][4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tezacaftor-d4 Related Antibodies
Clinical Trial
Molecular Weight

524.52

Formula

C26H23D4F3N2O6
CAS No.
Unlabeled CAS

1152311-62-0
Appearance

Solid

Color

White to off-white

SMILES

FC1=C(C=C2C(N(C(C(C)(C)CO)=C2)C[C@@H](O)CO)=C1)NC(C3(C4=CC=C(OC(F)(O5)F)C5=C4)C([2H])([2H])C3([2H])[2H])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (95.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : 50 mg/mL (95.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9065 mL 9.5325 mL 19.0650 mL
5 mM 0.3813 mL 1.9065 mL 3.8130 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥97.0%

COA (260 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / DMSO 1 mM 1.9065 mL 9.5325 mL 19.0650 mL 47.6626 mL
5 mM 0.3813 mL 1.9065 mL 3.8130 mL 9.5325 mL
10 mM 0.1907 mL 0.9533 mL 1.9065 mL 4.7663 mL
15 mM 0.1271 mL 0.6355 mL 1.2710 mL 3.1775 mL
20 mM 0.0953 mL 0.4766 mL 0.9533 mL 2.3831 mL
25 mM 0.0763 mL 0.3813 mL 0.7626 mL 1.9065 mL
30 mM 0.0636 mL 0.3178 mL 0.6355 mL 1.5888 mL
40 mM 0.0477 mL 0.2383 mL 0.4766 mL 1.1916 mL
50 mM 0.0381 mL 0.1907 mL 0.3813 mL 0.9533 mL
60 mM 0.0318 mL 0.1589 mL 0.3178 mL 0.7944 mL
80 mM 0.0238 mL 0.1192 mL 0.2383 mL 0.5958 mL
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Tezacaftor-d4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tezacaftor-d41961280-24-9VX-661-d4CFTRAutophagyCystic fibrosis transmembrane conductance regulatorInhibitorinhibitorinhibit

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